Hedvig Tamman
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Explore the profile of Hedvig Tamman including associated specialties, affiliations and a list of published articles.
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16
Citations
234
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Recent Articles
1.
Niault T, Talavera A, Le Cam E, Baconnais S, Skovgaard O, Fournes F, et al.
Nat Commun
. 2025 Jan;
16(1):485.
PMID: 39779702
The replication of the two chromosomes in the pathogenic bacterium Vibrio cholerae is coordinated by the binding of initiator protein RctB to a checkpoint sequence, crtS. Replication of crtS on...
2.
Brauer A, Rosendahl S, Kangsep A, Lewanczyk A, Rikberg R, Horak R, et al.
Environ Microbiol
. 2024 Jun;
26(6):e16671.
PMID: 38863081
The environmental bacterium, Pseudomonas putida, possesses a broad spectrum of metabolic pathways. This makes it highly promising for use in biotechnological production as a cell factory, as well as in...
3.
Tamman H, Ernits K, Roghanian M, Ainelo A, Julius C, Perrier A, et al.
Nat Chem Biol
. 2022 Dec;
19(3):334-345.
PMID: 36470996
Stringent factors orchestrate bacterial cell reprogramming through increasing the level of the alarmones (p)ppGpp. In Beta- and Gammaproteobacteria, SpoT hydrolyzes (p)ppGpp to counteract the synthetase activity of RelA. However, structural...
4.
Zhang T, Tamman H, Coppieters t Wallant K, Kurata T, LeRoux M, Srikant S, et al.
Nature
. 2022 Nov;
612(7938):132-140.
PMID: 36385533
Bacteria have evolved diverse immunity mechanisms to protect themselves against the constant onslaught of bacteriophages. Similar to how eukaryotic innate immune systems sense foreign invaders through pathogen-associated molecular patterns (PAMPs),...
5.
Mojr V, Roghanian M, Tamman H, Do Pham D, Petrova M, Pohl R, et al.
ACS Chem Biol
. 2021 Sep;
16(9):1680-1691.
PMID: 34477366
While alarmone nucleotides guanosine-3',5'-bisdiphosphate (ppGpp) and guanosine-5'-triphosphate-3'-diphosphate (pppGpp) are archetypical bacterial second messengers, their adenosine analogues ppApp (adenosine-3',5'-bisdiphosphate) and pppApp (adenosine-5'-triphosphate-3'-diphosphate) are toxic effectors that abrogate bacterial growth. The alarmones...
6.
Roghanian M, Van Nerom K, Takada H, Caballero-Montes J, Tamman H, Kudrin P, et al.
Mol Cell
. 2021 Aug;
81(16):3310-3322.e6.
PMID: 34416138
Amino acid starvation is sensed by Escherichia coli RelA and Bacillus subtilis Rel through monitoring the aminoacylation status of ribosomal A-site tRNA. These enzymes are positively regulated by their product-the...
7.
Kurata T, Brodiazhenko T, Oliveira S, Roghanian M, Sakaguchi Y, Turnbull K, et al.
Mol Cell
. 2021 Jun;
81(15):3160-3170.e9.
PMID: 34174184
RelA-SpoT Homolog (RSH) enzymes control bacterial physiology through synthesis and degradation of the nucleotide alarmone (p)ppGpp. We recently discovered multiple families of small alarmone synthetase (SAS) RSH acting as toxins...
8.
Rosendahl S, Tamman H, Brauer A, Remm M, Horak R
Sci Rep
. 2020 Jun;
10(1):9230.
PMID: 32513960
Chromosomal toxin-antitoxin (TA) systems are widespread genetic elements among bacteria, yet, despite extensive studies in the last decade, their biological importance remains ambivalent. The ability of TA-encoded toxins to affect...
9.
Tamman H, Van Nerom K, Takada H, Vandenberk N, Scholl D, Polikanov Y, et al.
Nat Chem Biol
. 2020 May;
16(8):834-840.
PMID: 32393900
Bifunctional Rel stringent factors, the most abundant class of RelA/SpoT homologs, are ribosome-associated enzymes that transfer a pyrophosphate from ATP onto the 3' of guanosine tri-/diphosphate (GTP/GDP) to synthesize the...
10.
Van Nerom K, Tamman H, Takada H, Hauryliuk V, Garcia-Pino A
Acta Crystallogr F Struct Biol Commun
. 2019 Aug;
75(Pt 8):561-569.
PMID: 31397328
The stringent response, controlled by (p)ppGpp, enables bacteria to trigger a strong phenotypic resetting that is crucial to cope with adverse environmental changes and is required for stress survival and...