Purpose: Measure associations between clinicopathological and immunohistochemical human Mut-L homologue 1 (hMLH1) gene, and human Mut-L homologue 2 (hMSH2) genes, variables in recurrent AMBs. Methods: This study consisted of a...

Relationship between tumor thickness and GATA3 immunoexpression in lip and tongue squamous cell carcinomas

Vital A, de Carvalho M, Maia C, Galvao H, de Souza L, Andrade Santos P

Oral Maxillofac Surg . 2024 Apr; 28(3):1259-1266. PMID: 38600414

Purpose: Lower lip squamous cell carcinomas (LLSCCs) exhibit lower levels of aggressiveness, low relations with metastases and better prognosis when compared with intraoral squamous cell carcinomas. Differently from the oral...

Immunohistochemical expression of beta-catenin, BMP4 and TGF-beta in odontomas

Franca G, Pires H, Silva W, de Morais E, Freitas R, de Souza L, et al.

Anat Histol Embryol . 2024 Feb; 53(2):e13024. PMID: 38409855

Changes in the expression of nuclear β-catenin are responsible for tumorigenesis. Beta-catenin acts synergistically with the TGF-β/BMPs pathway. This interaction leads to greater dentin deposition and may explain the differences...

Higher immunoexpression of CK14 from the Wnt-1/β-catenin pathway in the development of odontomas

Franca G, Carlan L, Pires H, Oliveira C, Andrade Santos P, Galvao H

Braz Dent J . 2023 Dec; 34(6):110-120. PMID: 38133085

Tooth development depends on a series of reciprocal signaling interactions between the oral epithelium and ectomesenchyme. This study aimed to investigate the role of CK14, a protein involved in Wnt-1/β-catenin...

EGFR, VEGF, and angiogenesis promote the development of lipoma in the oral cavity

Silva W, Pires H, Franca G, Freitas R, Morais H, Galvao H

Braz Dent J . 2023 May; 34(2):113-121. PMID: 37194849

This study aimed to detect, quantify and compare the immunohistochemical expression of EGFR and VEGF and microvessel count (MVC) in oral lipomas, and to correlate the findings with clinical and...

SNAIL1 is involved in the control of the epithelial-mesenchymal transition in oral tongue squamous cell carcinoma

de Morais E, Morais H, Franca G, Teo F, Galvao H, Salo T, et al.

Oral Surg Oral Med Oral Pathol Oral Radiol . 2023 Mar; 135(4):530-538. PMID: 36918320

Objective: The aim of the present study was to investigate the role of SNAIL1, E-cadherin, and N-cadherin immunoexpression in oral tongue carcinogenesis. In addition, we evaluated in vitro the impact...

Verruciform xanthoma associated with lichen planus

Medeiros C, Franca G, Silva W, Felipe J, Galvao H, de Oliveira P

Autops Case Rep . 2022 Mar; 12:e2021360. PMID: 35252052

Verruciform xanthoma (VX) is a rare benign lesion of unknown etiology, with a rough or papillary aspect, painless, sessile, well-defined, most lesions do not exceed 2 cm in their largest...

Biomarkers involved in the proliferation of the odontogenic keratocyst, glandular odontogenic cyst and botryoid odontogenic cyst

Junior J, Franca G, da Silva Barros C, Felix F, Silva W, de Lucena H, et al.

Oral Maxillofac Surg . 2022 Jan; 26(4):655-662. PMID: 35059898

Introduction: Odontogenic cysts are a heterogeneous group of lesions with varied clinical behavior. Objective: To analyze the expression of the epidermal growth factor receptor (EGFR), Cyclin D1, and transcription factor...

Franca G, de Macedo Andrade A, Felix F, Silva W, Almeida D, Leite R, et al.

Arch Oral Biol . 2021 Sep; 131:105267. PMID: 34592489

Objective: To aim of this systematic review was to explore the relationship between Human papillomavirus (HPV) and epithelial-mesenchymal transition (EMT) related to the prognosis of oropharyngeal squamous cell carcinoma (OPSCC)....

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Five-year survival and prognostic factors for oropharyngeal squamous cell carcinoma: retrospective cohort of a cancer center

Franca G, Silva W, Medeiros C, Junior J, Santos E, Galvao H

Oral Maxillofac Surg . 2021 Jul; 26(2):261-269. PMID: 34297231

Introduction: Oropharyngeal cancer is characterized by high morbidity and mortality. Prognostic factors for this cancer are therefore useful to predict overall survival and may provide additional therapeutic targets. Objective: To...