Heather L Watt
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Explore the profile of Heather L Watt including associated specialties, affiliations and a list of published articles.
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9
Citations
183
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Recent Articles
1.
Watt H, Rachid Z, Jean-Claude B
J Signal Transduct
. 2012 Apr;
2012:282050.
PMID: 22523681
Recently, we reported the combination of multitargeted ErbB1 inhibitor-DNA damage combi-molecules with OCT in order to downregulate ErbB1 and activate SSTRs. Absence of translation to cell kill was believed to...
2.
Scheede-Bergdahl C, Watt H, Trutschnigg B, Kilgour R, Haggarty A, Lucar E, et al.
Clin Nutr
. 2011 Aug;
31(1):85-8.
PMID: 21855185
Background & Aims: Despite the descriptive presence of cancer cachexia (CC) in clinical practice, the underlying mechanisms and diagnostic definition have not been clearly identified. Recent work, attempting to establish...
3.
Kharmate G, Rajput P, Watt H, Somvanshi R, Chaudhari N, Qiu X, et al.
Biochim Biophys Acta
. 2011 Mar;
1813(6):1172-89.
PMID: 21419811
Epidermal growth factor (EGF) regulates normal and tumor cell proliferation via epidermal growth factor receptor (EGFR) phosphorylation, homo- or heterodimerization and activation of mitogen-activated protein kinases (MAPKs) and PI3K/AKT cell...
4.
Kharmate G, Rajput P, Watt H, Somvanshi R, Chaudhari N, Qiu X, et al.
Endocrinology
. 2010 Dec;
152(3):931-45.
PMID: 21190959
Epidermal growth factor through the stimulation of epidermal growth factor receptor (EGFR) plays a critical role in the activation of MAPKs and phosphatidylinositol-3-protein kinase/AKT cell survival pathways attributed in many...
5.
Watt H, Kharmate G, Kumar U
Cell Signal
. 2008 Dec;
21(3):428-39.
PMID: 19070659
The role of somatostatin (SST) and epidermal growth factor (EGF) in breast cancer is undisputed; however, the molecular mechanisms underlying their antiproliferative or proliferative effects are not well understood. We...
6.
Watt H, Kharmate G, Kumar U
Mol Cell Endocrinol
. 2008 Mar;
286(1-2):251-61.
PMID: 18308465
The biological effects of the neuropeptide somatostatin (SST) are mediated via a family of five somatostatin receptors (SSTRs) belonging to a family of G-protein-coupled receptors (GPCRs). SSTR regulate the secretion...
7.
Baragli A, Alturaihi H, Watt H, Abdallah A, Kumar U
Cell Signal
. 2007 Aug;
19(11):2304-16.
PMID: 17706924
Somatostatin and dopamine receptors are well expressed and co-localized in several brain regions, suggesting the possibility of functional interactions. In the present study we used a combination of pharmacological, biochemical...
8.
Watt H, Kumar U
Cancer Cell Int
. 2006 Mar;
6:5.
PMID: 16519802
Background: Somatostatin receptor (SSTR) expression is positively correlated with tumor size and inversely correlated with epidermal growth factor receptor (ErbB) levels and tumor differentiation. In the present study, we compared...
9.
Ramirez J, Watt H, Rocheville M, Kumar U
Biochim Biophys Acta
. 2005 May;
1669(2):182-92.
PMID: 15893521
We have previously shown that the human somatostatin receptor type 1 (hSSTR1) does not undergo agonist-induced internalization, but is instead up-regulated at the membrane upon prolonged somatostatin (SST) exposure. The...