Heather L Parrish
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Explore the profile of Heather L Parrish including associated specialties, affiliations and a list of published articles.
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12
Citations
165
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Recent Articles
1.
Lee M, Tuohy P, Kim C, Yost P, Lichauco K, Parrish H, et al.
Elife
. 2024 Apr;
12.
PMID: 38639990
CD4 T cell activation is driven by five-module receptor complexes. The T cell receptor (TCR) is the receptor module that binds composite surfaces of peptide antigens embedded within MHCII molecules...
2.
Lee M, Tuohy P, Kim C, Yost P, Lichauco K, Parrish H, et al.
bioRxiv
. 2023 May;
PMID: 37214965
CD4 T cell activation is driven by 5-module receptor complexes. The T cell receptor (TCR) is the receptor module that binds composite surfaces of peptide antigens embedded within MHCII molecules...
3.
Kim C, Parrish H, Kuhns M
J Immunol
. 2022 Nov;
209(10):2033-2041.
PMID: 36426940
T cells play a central role in adaptive immunity by recognizing peptide Ags presented by MHC molecules (pMHC) via their clonotypic TCRs. αβTCRs are heterodimers, consisting of TCRα and TCRβ...
4.
Lee M, Tuohy P, Kim C, Lichauco K, Parrish H, Van Doorslaer K, et al.
Elife
. 2022 Jul;
11.
PMID: 35861317
CD4 T cells use T cell receptor (TCR)-CD3 complexes, and CD4, to respond to peptide antigens within MHCII molecules (pMHCII). We report here that, through ~435 million years of evolution...
5.
Kobayashi S, Thelin M, Parrish H, Deshpande N, Lee M, Karimzadeh A, et al.
Proc Natl Acad Sci U S A
. 2020 Nov;
117(46):28950-28959.
PMID: 33139567
T cells express clonotypic T cell receptors (TCRs) that recognize peptide antigens in the context of class I or II MHC molecules (pMHCI/II). These receptor modules associate with three signaling...
6.
Glassman C, Parrish H, Lee M, Kuhns M
Cell Rep
. 2018 Feb;
22(5):1263-1275.
PMID: 29386113
CD4 T cells convert the time that T cell receptors (TCRs) interact with peptides embedded within class II major histocompatibility complex molecules (pMHCII) into signals that direct cell-fate decisions. In...
7.
Glassman C, Parrish H, Deshpande N, Kuhns M
J Immunol
. 2016 May;
196(11):4713-22.
PMID: 27183595
TCRs relay information about peptides embedded within MHC molecules (pMHC) to the ITAMs of the associated CD3γε, CD3δε, and CD3ζζ signaling modules. CD4 then recruits the Src kinase p56(Lck) (Lck)...
8.
Parrish H, Glassman C, Keenen M, Deshpande N, Bronnimann M, Kuhns M
PLoS One
. 2016 Mar;
11(3):e0150876.
PMID: 26930656
No abstract available.
9.
Parrish H, Deshpande N, Vasic J, Kuhns M
Proc Natl Acad Sci U S A
. 2016 Feb;
113(11):3000-5.
PMID: 26831112
How T cells become restricted to binding antigenic peptides within class I or class II major histocompatibility complex molecules (pMHCI or pMHCII, respectively) via clonotypic T-cell receptors (TCRs) remains debated....
10.
Lee M, Glassman C, Deshpande N, Badgandi H, Parrish H, Uttamapinant C, et al.
Immunity
. 2015 Aug;
43(2):227-39.
PMID: 26231119
The eight-subunit T cell receptor (TCR)-CD3 complex is the primary determinant for T cell fate decisions. Yet how it relays ligand-specific information across the cell membrane for conversion to chemical...