Heather L Mentrup
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Explore the profile of Heather L Mentrup including associated specialties, affiliations and a list of published articles.
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8
Citations
85
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Recent Articles
1.
Epithelial NAD depletion drives mitochondrial dysfunction and contributes to intestinal inflammation
Novak E, Crawford E, Mentrup H, Griffith B, Fletcher D, Flanagan M, et al.
Front Immunol
. 2023 Sep;
14:1231700.
PMID: 37744380
Introduction: We have previously demonstrated that a pathologic downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1α) within the intestinal epithelium contributes to the pathogenesis of inflammatory bowel disease (IBD). However,...
2.
Crawford E, Mentrup H, Novak E, Mollen K
J Vis Exp
. 2023 Jun;
(196).
PMID: 37335108
The intestinal epithelium plays an essential role in human health, providing a barrier between the host and the external environment. This highly dynamic cell layer provides the first line of...
3.
Burr A, Ji J, Ozler K, Mentrup H, Eskiocak O, Yueh B, et al.
Cell Mol Gastroenterol Hepatol
. 2023 May;
16(2):287-316.
PMID: 37172822
Background & Aims: The colonic epithelium requires continuous renewal by crypt resident intestinal stem cells (ISCs) and transit-amplifying (TA) cells to maintain barrier integrity, especially after inflammatory damage. The diet...
4.
Khan S, Mentrup H, Novak E, Siow V, Wang Q, Crawford E, et al.
FASEB J
. 2022 Mar;
36(5):e22282.
PMID: 35344224
Inflammatory bowel disease (IBD) represents a set of idiopathic and chronic inflammatory diseases of the gastrointestinal tract. Central to the pathogenesis of IBD is a dysregulation of normal intestinal epithelial...
5.
Lamade A, Wu L, Dar H, Mentrup H, Shrivastava I, Epperly M, et al.
Redox Biol
. 2022 Feb;
50:102232.
PMID: 35101798
Ferroptosis and necroptosis are two pro-inflammatory cell death programs contributing to major pathologies and their inhibition has gained attention to treat a wide range of disease states. Necroptosis relies on...
6.
Vincent G, Novak E, Siow V, Cunningham K, Griffith B, Comerford T, et al.
Antioxid Redox Signal
. 2020 Feb;
33(1):1-19.
PMID: 32103677
Mitochondrial stress and dysfunction within the intestinal epithelium are known to contribute to the pathogenesis of inflammatory bowel disease (IBD). However, the importance of mitophagy during intestinal inflammation remains poorly...
7.
Mentrup H, Hartman A, Thames E, Basheer W, Matesic L
Differentiation
. 2018 Jan;
99:51-61.
PMID: 29309986
Maintenance of the intestinal mucosa is driven by local signals that coordinate epithelial proliferation, differentiation, and turnover in order to separate antigenic luminal contents from the host's immune system. Breaches...
8.
Basheer W, Harris B, Mentrup H, Abreha M, Thames E, Lea J, et al.
J Mol Cell Cardiol
. 2015 Sep;
88:1-13.
PMID: 26386426
Gap junctions (GJ) are intercellular channels composed of connexin subunits that play a critical role in a diverse number of cellular processes in all tissue types. In the heart, GJs...