Hayley Davis
Overview
Explore the profile of Hayley Davis including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
899
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0
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Recent Articles
1.
Koppens M, Davis H, Valbuena G, Mulholland E, Nasreddin N, Colombe M, et al.
Gastroenterology
. 2021 Apr;
161(1):239-254.e9.
PMID: 33819486
Background & Aims: In homeostasis, intestinal cell fate is controlled by balanced gradients of morphogen signaling. The bone morphogenetic protein (BMP) pathway has a physiological, prodifferentiation role, predominantly inferred through...
2.
Kleeman S, Koelzer V, Jones H, Gil Vazquez E, Davis H, East J, et al.
Gut
. 2019 Sep;
69(6):1092-1103.
PMID: 31563876
Objective: Pathological Wnt pathway activation is a conserved hallmark of colorectal cancer. Wnt-activating mutations can be divided into: i) ligand-independent (LI) alterations in intracellular signal transduction proteins (, β-catenin), causing...
3.
Thomas R, Trapani D, Goodyer-Sait L, Tomkova M, Fernandez-Rozadilla C, Sahnane N, et al.
Sci Rep
. 2019 Sep;
9(1):13463.
PMID: 31530880
Expression of the mismatch repair gene MutL homolog 1 (MLH1) is silenced in a clinically important subgroup of sporadic colorectal cancers. These cancers exhibit hypermutability with microsatellite instability (MSI) and...
4.
Cross W, Kovac M, Mustonen V, Temko D, Davis H, Baker A, et al.
Nat Ecol Evol
. 2018 Sep;
2(10):1661-1672.
PMID: 30177804
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome and exome sequencing of 24 benign and malignant colorectal tumours, we...
5.
Davis H, Ritchie E, Avitabile S, Doherty T, Nimmo D
R Soc Open Sci
. 2018 May;
5(4):172055.
PMID: 29765661
Fire shapes the composition and functioning of ecosystems globally. In many regions, fire is actively managed to create diverse patch mosaics of fire-ages under the assumption that a diversity of...
6.
Irshad S, Bansal M, Guarnieri P, Davis H, Al Haj Zen A, Baran B, et al.
J Pathol
. 2017 Mar;
242(2):178-192.
PMID: 28299802
The functional role of bone morphogenetic protein (BMP) signalling in colorectal cancer (CRC) is poorly defined, with contradictory results in cancer cell line models reflecting the inherent difficulties of assessing...
7.
Hernandez M, Patel B, Hey F, Giblett S, Davis H, Pritchard C
Cell Signal
. 2016 Feb;
28(6):561-71.
PMID: 26898828
The (V600E)BRAF oncogenic mutation is detected in a wide range of human cancers and induces hyperactivation of the downstream MEK-ERK signalling cascade. Although output of the BRAF-MEK-ERK pathway is regulated...
8.
Davis H, Raja E, Miyazono K, Tsubakihara Y, Moustakas A
Cytokine Growth Factor Rev
. 2015 Dec;
27:81-92.
PMID: 26678814
The bone morphogenetic proteins (BMPs) play fundamental roles in embryonic development and control differentiation of a diverse set of cell types. It is therefore of no surprise that the BMPs...
9.
Biswas S, Davis H, Irshad S, Sandberg T, Worthley D, Leedham S
J Pathol
. 2015 May;
237(2):135-45.
PMID: 25974319
The conventional model of intestinal epithelial architecture describes a unidirectional tissue organizational hierarchy with stem cells situated at the crypt base and daughter cells proliferating and terminally differentiating as they...
10.
Davis H, Irshad S, Bansal M, Rafferty H, Boitsova T, Bardella C, et al.
Nat Med
. 2014 Nov;
21(1):62-70.
PMID: 25419707
Hereditary mixed polyposis syndrome (HMPS) is characterized by the development of mixed-morphology colorectal tumors and is caused by a 40-kb genetic duplication that results in aberrant epithelial expression of the...