Harveen Dhillon
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Explore the profile of Harveen Dhillon including associated specialties, affiliations and a list of published articles.
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12
Citations
1716
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Recent Articles
1.
Jain I, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, et al.
Science
. 2016 Feb;
352(6281):54-61.
PMID: 26917594
Defects in the mitochondrial respiratory chain (RC) underlie a spectrum of human conditions, ranging from devastating inborn errors of metabolism to aging. We performed a genome-wide Cas9-mediated screen to identify...
2.
High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons
Klockener T, Hess S, Belgardt B, Paeger L, Verhagen L, Husch A, et al.
Nat Neurosci
. 2011 Jun;
14(7):911-8.
PMID: 21642975
Steroidogenic factor 1 (SF-1)-expressing neurons of the ventromedial hypothalamus (VMH) control energy homeostasis, but the role of insulin action in these cells remains undefined. We show that insulin activates phosphatidylinositol-3-OH...
3.
Xu Y, Hill J, Fukuda M, Gautron L, Sohn J, Kim K, et al.
Cell Metab
. 2010 Jul;
12(1):88-95.
PMID: 20620998
Phosphatidyl inositol 3-kinase (PI3K) signaling in the hypothalamus has been implicated in the regulation of energy homeostasis, but the critical brain sites where this intracellular signal integrates various metabolic cues...
4.
Hawke Z, Ivanov T, Bechtold D, Dhillon H, Lowell B, Luckman S
J Neurosci
. 2009 Nov;
29(47):14828-35.
PMID: 19940178
The adipose-derived hormone, leptin, was discovered over 10 years ago, but only now are we unmasking its downstream pathways which lead to reduced energy intake (feeding) and increased energy expenditure...
5.
Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell B, Maratos-Flier E, et al.
Endocrinology
. 2008 Aug;
149(11):5654-61.
PMID: 18669597
Suppressor of cytokine signaling 3 (Socs3) has been identified as a mediator of central leptin resistance, but the identity of specific neurons in which Socs3 acts to suppress leptin signaling...
6.
Tong Q, Ye C, McCrimmon R, Dhillon H, Choi B, Kramer M, et al.
Cell Metab
. 2007 May;
5(5):383-93.
PMID: 17488640
The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely...
7.
Dhillon H, Zigman J, Ye C, Lee C, McGovern R, Tang V, et al.
Neuron
. 2006 Jan;
49(2):191-203.
PMID: 16423694
Leptin, an adipocyte-derived hormone, acts directly on the brain to control food intake and energy expenditure. An important question is the identity of first-order neurons initiating leptin's anti-obesity effects. A...
8.
Kershaw E, Morton N, Dhillon H, Ramage L, Seckl J, Flier J
Diabetes
. 2005 Mar;
54(4):1023-31.
PMID: 15793240
Local glucocorticoid (GC) action depends on intracellular GC metabolism by 11beta-hydroxysteroid dehydrogenases (11betaHSDs). 11betaHSD1 activates GCs, while 11betaHSD2 inactivates GCs. Adipocyte-specific amplification of GCs through transgenic overexpression of 11betaHSD1 produces...
9.
Bachman E, Hampton T, Dhillon H, Amende I, Wang J, Morgan J, et al.
Endocrinology
. 2004 Mar;
145(6):2767-74.
PMID: 15016719
Hyperthyroidism and states of adrenergic hyperactivity have many common clinical features, suggesting similar pathogenic mechanisms of action. The widespread use of beta-adrenergic receptor (betaAR) antagonists (beta-blockers) to treat hyperthyroidism has...
10.
Bachman E, Dhillon H, Zhang C, Cinti S, Bianco A, Kobilka B, et al.
Science
. 2002 Aug;
297(5582):843-5.
PMID: 12161655
Excessive caloric intake is thought to be sensed by the brain, which then activates thermogenesis as a means of preventing obesity. The sympathetic nervous system, through beta-adrenergic receptor (betaAR) action...