Harlan D Caldwell
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Explore the profile of Harlan D Caldwell including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Karanovic U, Lei L, Martens C, Barbian K, McClarty G, Caldwell H, et al.
Pathog Dis
. 2023 Oct;
81.
PMID: 37804183
Chlamydia trachomatis is an obligate intracellular bacterium that causes blinding trachoma and sexually transmitted disease. The chlamydial plasmid is a critical virulence factor in the pathogenesis of these diseases. Plasmid...
2.
DeBoer A, Lei L, Yang C, Martens C, Anzick S, Antonioli-Schmit S, et al.
Infect Immun
. 2023 May;
91(7):e0009623.
PMID: 37255490
All members of the family Chlamydiaceae have lipopolysaccharides (LPS) that possess a shared carbohydrate trisaccharide antigen, 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) that is functionally uncharacterized. A single gene, genus-specific epitope (), is...
3.
Yang C, Lei L, Collins J, Briones M, Ma L, Sturdevant G, et al.
Nat Commun
. 2021 Sep;
12(1):5454.
PMID: 34526512
Chlamydia trachomatis infection causes severe inflammatory disease resulting in blindness and infertility. The pathophysiology of these diseases remains elusive but myeloid cell-associated inflammation has been implicated. Here we show NLRP3...
4.
Lei L, Yang C, Patton M, Smelkinson M, Dorward D, Ma L, et al.
mBio
. 2021 Jun;
12(3):e0117921.
PMID: 34101486
Chlamydia are obligate intracellular Gram-negative bacteria distinguished by a unique developmental biology confined within a parasitophorous vacuole termed an inclusion. The chlamydial plasmid is a central virulence factor in the...
5.
Yang C, Kari L, Lei L, Carlson J, Ma L, Couch C, et al.
mBio
. 2020 Aug;
11(4).
PMID: 32817110
is an obligate intracellular bacterial pathogen that causes blinding trachoma and sexually transmitted disease afflicting hundreds of millions of people globally. A fundamental but poorly understood pathophysiological characteristic of chlamydial...
6.
Yang C, Briones M, Chiou J, Lei L, Patton M, Ma L, et al.
mBio
. 2019 Apr;
10(2).
PMID: 31015326
is the most common bacterial cause of sexually transmitted infections. sexually transmitted infections are commonly asymptomatic, implying a pathogenic strategy for the evasion of innate inflammatory immune responses, a paradox...
7.
Patton D, Sweeney Y, Baldessari A, Cles L, Kari L, Sturdevant G, et al.
Infect Immun
. 2018 Feb;
86(5.
PMID: 29463617
The plasmid and inclusion membrane protein CT135 are virulence factors in the pathogenesis of murine female genital tract infection. To determine if these virulence factors play a similar role in...
8.
Patton M, Chen C, Yang C, McCorrister S, Grant C, Westmacott G, et al.
mBio
. 2018 Feb;
9(1).
PMID: 29382731
is an obligate intracellular bacterial pathogen that causes blinding trachoma and sexually transmitted disease. isolates are classified into 2 biovars-lymphogranuloma venereum (LGV) and trachoma-which are distinguished biologically by their natural...
9.
Yang C, Whitmire W, Sturdevant G, Bock K, Moore I, Caldwell H
Infect Immun
. 2017 May;
85(7).
PMID: 28461392
We studied infection and immunity of hysterectomized mice infected with and to determine if there were differences between these species in their ability to infect vaginal squamous epithelial cells independently...
10.
Yang C, Kari L, Sturdevant G, Song L, Patton M, Couch C, et al.
Pathog Dis
. 2017 Apr;
75(3).
PMID: 28369275
Chlamydia trachomatis is an obligate intracellular pathogen characterized by a unique biphasic developmental cycle that alternates between infectious and non-infectious organisms. Chlamydial ChxR is a transcriptional activator that has been...