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Hao-Xian Zhu

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Recent Articles
1.
Ma J, Xu T, Zhu H, Chen X, Li L, Zhao Z, et al.
Arthritis Rheumatol . 2025 Mar; PMID: 40026078
Objective: Activated T cells play a pivotal pathogenic role in the progression of Sjögren's disease (SjD); however, there are currently no targeted therapies specifically designed to address them. This study...
2.
Long J, Yang S, Bian Z, Zhu H, Ma M, Wang X, et al.
Adv Sci (Weinh) . 2024 Nov; 12(1):e2407284. PMID: 39494472
The specific mechanisms underlying effector pathways in autoimmune liver disease remain enigmatic and therefore constructing appropriate murine models to investigate disease pathogenesis becomes critical. A spontaneous severe murine model of...
3.
Zhu H, Yang S, Gao C, Bian Z, Chen X, Huang R, et al.
Nat Commun . 2024 Apr; 15(1):2936. PMID: 38580644
Primary biliary cholangitis (PBC) is a cholestatic autoimmune liver disease characterized by autoreactive T cell response against intrahepatic small bile ducts. Here, we use Il12bIl2ra mice (DKO mice) as a...
4.
Xu T, Zhu H, You X, Ma J, Li X, Luo P, et al.
JCI Insight . 2023 Mar; 8(8). PMID: 36881472
Primary Sjögren's syndrome (pSS) is a systemic autoimmune inflammatory disease mainly defined by T cell-dominated destruction of exocrine glands. Currently, CD8+ T cells are thought to be involved in the...
5.
Huang C, Zhu H, Yao Y, Bian Z, Zheng Y, Li L, et al.
J Autoimmun . 2019 Oct; 104:102333. PMID: 31564474
During host immune response, an initial and sufficient activation is required to avoid infection and cancer, yet an excessive activation bears the risk of autoimmune reactivity and disease development. This...