Hans C van Houwelingen
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Explore the profile of Hans C van Houwelingen including associated specialties, affiliations and a list of published articles.
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90
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3238
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Recent Articles
1.
Thomassen D, le Cessie S, van Houwelingen H, Steyerberg E
Stat Med
. 2024 Jan;
43(7):1384-1396.
PMID: 38297411
Clinical prediction models are estimated using a sample of limited size from the target population, leading to uncertainty in predictions, even when the model is correctly specified. Generally, not all...
2.
Putter H, van Houwelingen H
Stat Med
. 2022 Jan;
41(11):1901-1917.
PMID: 35098578
The problem of dynamic prediction with time-dependent covariates, given by biomarkers, repeatedly measured over time, has received much attention over the last decades. Two contrasting approaches have become in widespread...
3.
Andersen P, Pohar Perme M, van Houwelingen H, Cook R, Joly P, Martinussen T, et al.
Stat Med
. 2020 Oct;
40(1):185-211.
PMID: 33043497
This paper provides guidance for researchers with some mathematical background on the conduct of time-to-event analysis in observational studies based on intensity (hazard) models. Discussions of basic concepts like time...
4.
5.
van Geloven N, Swanson S, Ramspek C, Luijken K, van Diepen M, Morris T, et al.
Eur J Epidemiol
. 2020 May;
35(7):619-630.
PMID: 32445007
In this paper we study approaches for dealing with treatment when developing a clinical prediction model. Analogous to the estimand framework recently proposed by the European Medicines Agency for clinical...
6.
Putter H, Schumacher M, van Houwelingen H
Biom J
. 2020 Mar;
62(3):790-807.
PMID: 32128860
The Fine-Gray proportional subdistribution hazards model has been puzzling many people since its introduction. The main reason for the uneasy feeling is that the approach considers individuals still at risk...
7.
Steyerberg E, Nieboer D, Debray T, van Houwelingen H
Stat Med
. 2019 Aug;
38(22):4290-4309.
PMID: 31373722
Clinical prediction models aim to provide estimates of absolute risk for a diagnostic or prognostic endpoint. Such models may be derived from data from various studies in the context of...
8.
van Houwelingen H
Lifetime Data Anal
. 2018 Jul;
24(4):595-600.
PMID: 30022322
No abstract available.
9.
Dreno B, Thompson J, Smithers B, Santinami M, Jouary T, Gutzmer R, et al.
Lancet Oncol
. 2018 Jun;
19(7):916-929.
PMID: 29908991
Background: Despite newly approved treatments, metastatic melanoma remains a life-threatening condition. We aimed to evaluate the efficacy of the MAGE-A3 immunotherapeutic in patients with stage IIIB or IIIC melanoma in...
10.
Putter H, van Houwelingen H
Stat Biosci
. 2017 Dec;
9(2):489-503.
PMID: 29225713
Time-dependent Cox regression and landmarking are the two most commonly used approaches for the analysis of time-dependent covariates in time-to-event data. The estimated effect of the time-dependent covariate in a...