Hans-Michael Dosch
Overview
Explore the profile of Hans-Michael Dosch including associated specialties, affiliations and a list of published articles.
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11
Citations
445
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Recent Articles
1.
Knip M, Akerblom H, Al Taji E, Becker D, Bruining J, Castano L, et al.
JAMA
. 2018 Jan;
319(1):38-48.
PMID: 29297078
Importance: Early exposure to complex dietary proteins may increase the risk of type 1 diabetes in children with genetic disease susceptibility. There are no intact proteins in extensively hydrolyzed formulas....
2.
Knip M, Akerblom H, Becker D, Dosch H, Dupre J, Fraser W, et al.
JAMA
. 2014 Jun;
311(22):2279-87.
PMID: 24915259
Importance: The disease process leading to clinical type 1 diabetes often starts during the first years of life. Early exposure to complex dietary proteins may increase the risk of β-cell...
3.
Hadley D, Cheung R, Becker D, Girgis R, Palmer J, Cuthbertson D, et al.
Clin Vaccine Immunol
. 2013 Dec;
21(2):203-11.
PMID: 24334687
Broad consensus assigns T lymphocytes fundamental roles in inflammatory, infectious, and autoimmune diseases. However, clinical investigations have lacked fully characterized and validated procedures, equivalent to those of widely practiced biochemical...
4.
Cholecalciferol plus calcium suppresses abnormal PBMC reactivity in patients with multiple sclerosis
Kimball S, Vieth R, Dosch H, Bar-Or A, Cheung R, Gagne D, et al.
J Clin Endocrinol Metab
. 2011 Jun;
96(9):2826-34.
PMID: 21697250
Context: The active metabolite of vitamin D, 1,25-dihydroxyvitamin D [1,25(OH)(2)D], is a potent modulator of immune cells in vitro. Objective: Our objective was to determine whether the sun-dependent nutrient, cholecalciferol,...
5.
Knip M, Virtanen S, Seppa K, Ilonen J, Savilahti E, Vaarala O, et al.
N Engl J Med
. 2010 Nov;
363(20):1900-8.
PMID: 21067382
Background: Early exposure to complex dietary proteins may increase the risk of beta-cell autoimmunity and type 1 diabetes in children with genetic susceptibility. We tested the hypothesis that supplementing breast...
6.
Tsui H, Winer S, Chan Y, Truong D, Tang L, Yantha J, et al.
Ann N Y Acad Sci
. 2009 Jan;
1150:32-42.
PMID: 19120264
Type 1 diabetes (T1D) is caused by autoimmune beta cell destruction. The early events triggering T1D and the forces that keep diabetic autoimmunity pancreas specific have been unclear. Our discovery...
7.
Tsui H, Chan Y, Tang L, Winer S, Cheung R, Paltser G, et al.
Diabetes
. 2008 Jan;
57(4):918-28.
PMID: 18198358
Objective: Type 1 diabetes reflects autoimmune destruction of beta-cells and peri-islet Schwann cells (pSCs), but the mechanisms of pSC death and the T-cell epitopes involved remain unclear. Research Design And...
8.
Banwell B, Bar-Or A, Cheung R, Kennedy J, Krupp L, Becker D, et al.
Ann Neurol
. 2007 Oct;
63(1):98-111.
PMID: 17932975
Objectives: Pediatric-onset multiple sclerosis offers a unique window into early targets and mechanisms of immune dysregulation. It is unknown whether heightened T-cell reactivities documented in adult patients, to both target-organ...
9.
Forooghian F, Cheung R, Smith W, OConnor P, Dosch H
J Clin Immunol
. 2007 Apr;
27(4):388-96.
PMID: 17436063
Introduction: Although myelin autoimmunity is known to be a major factor in the pathogenesis of multiple sclerosis (MS), the role of nonmyelin antigens is less clear. Given the complexity of...
10.
Mastronardi F, Wood D, Mei J, Raijmakers R, Tseveleki V, Dosch H, et al.
J Neurosci
. 2006 Nov;
26(44):11387-96.
PMID: 17079667
Modification of arginine residues by citrullination is catalyzed by peptidylarginine deiminases (PADs), of which five are known, generating irreversible protein structural modifications. We have shown previously that enhanced citrullination of...