Hannele Mattsson
Overview
Explore the profile of Hannele Mattsson including associated specialties, affiliations and a list of published articles.
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7
Citations
1555
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Recent Articles
1.
Kurki M, Karjalainen J, Palta P, Sipila T, Kristiansson K, Donner K, et al.
Nature
. 2023 Feb;
615(7952):E19.
PMID: 36829046
No abstract available.
2.
Kurki M, Karjalainen J, Palta P, Sipila T, Kristiansson K, Donner K, et al.
Nature
. 2023 Jan;
613(7944):508-518.
PMID: 36653562
Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%)....
3.
Clark D, Okada Y, Moore K, Mason D, Pirastu N, Gandin I, et al.
Nat Commun
. 2019 Nov;
10(1):4957.
PMID: 31673082
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because...
4.
Diogo D, Tian C, Franklin C, Alanne-Kinnunen M, March M, Spencer C, et al.
Nat Commun
. 2018 Oct;
9(1):4285.
PMID: 30327483
Phenome-wide association studies (PheWAS) have been proposed as a possible aid in drug development through elucidating mechanisms of action, identifying alternative indications, or predicting adverse drug events (ADEs). Here, we...
5.
Mace A, Tuke M, Deelen P, Kristiansson K, Mattsson H, Noukas M, et al.
Nat Commun
. 2017 Oct;
8(1):744.
PMID: 28963451
There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV association meta-analysis on anthropometric traits in...
6.
Joshi P, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, et al.
Nature
. 2015 Jul;
523(7561):459-462.
PMID: 26131930
Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the...
7.
Auro K, Joensuu A, Fischer K, Kettunen J, Salo P, Mattsson H, et al.
Nat Commun
. 2014 Aug;
5:4708.
PMID: 25144627
The ageing of the global population calls for a better understanding of age-related metabolic consequences. Here we report the effects of age, sex and menopause on serum metabolites in 26,065...