Hanna E Silber
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Explore the profile of Hanna E Silber including associated specialties, affiliations and a list of published articles.
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8
Citations
181
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Recent Articles
1.
Silber H, Burgener C, Letellier I, Peyrou M, Jung M, King J, et al.
Pharm Res
. 2010 Oct;
27(12):2633-45.
PMID: 20922466
Purpose: The purpose of this population analysis was to characterize the pharmacokinetic properties of robenacoxib in blood and stifle joint synovial fluid of dogs. Methods: Data were obtained from two...
2.
Silber H, Jauslin P, Frey N, Karlsson M
Basic Clin Pharmacol Toxicol
. 2010 Jan;
106(3):189-94.
PMID: 20050839
The integrated glucose-insulin model was originally developed on a variety of intravenous glucose provocation experiments in healthy volunteers and type 2 diabetic patients. The model, which simultaneously describes time-courses of...
3.
Silber H, Frey N, Karlsson M
J Clin Pharmacol
. 2009 Nov;
50(3):246-56.
PMID: 19940230
The extension of the previously developed integrated models for glucose and insulin (IGI) to include the oral glucose tolerance test (OGTT) in healthy volunteers could be valuable to better understand...
4.
Silber H, Nyberg J, Hooker A, Karlsson M
J Pharmacokinet Pharmacodyn
. 2009 Jun;
36(3):281-95.
PMID: 19554431
Intravenous glucose tolerance test (IVGTT) provocations are informative, but complex and laborious, for studying the glucose-insulin system. The objective of this study was to evaluate, through optimal design methodology, the...
5.
Silber H, Kjellsson M, Karlsson M
J Pharmacokinet Pharmacodyn
. 2009 Feb;
36(1):81-99.
PMID: 19219538
It has been shown that when using the FOCE method in NONMEM, the likelihood ratio test (LRT) can be sensitive to the use of an inappropriate estimation method in that...
6.
Dansirikul C, Silber H, Karlsson M
J Pharmacokinet Pharmacodyn
. 2008 May;
35(3):269-83.
PMID: 18446428
A few approaches for handling baseline responses are available for use in pharmacokinetic (PK)-pharmacodynamic (PD) analysis. They include: (method 1-B1) estimation of the typical value and interindividual variability (IIV) of...
7.
An integrated glucose-insulin model to describe oral glucose tolerance test data in type 2 diabetics
Jauslin P, Silber H, Frey N, Gieschke R, Simonsson U, Jorga K, et al.
J Clin Pharmacol
. 2007 Oct;
47(10):1244-55.
PMID: 17906159
An integrated model for the glucose-insulin system describing oral glucose tolerance test data was developed, extending on a previously introduced model for intravenous glucose provocations. Model extensions comprised the description...
8.
Silber H, Jauslin P, Frey N, Gieschke R, Simonsson U, Karlsson M
J Clin Pharmacol
. 2007 Sep;
47(9):1159-71.
PMID: 17766701
An integrated model for the regulation of glucose and insulin concentrations following intravenous glucose provocations in healthy volunteers and type 2 diabetic patients was developed. Data from 72 individuals were...