Alpha 2.0
Login Register
» Authors » Hamdi M Hassaneen

Hamdi M Hassaneen

Explore the profile of Hamdi M Hassaneen including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 19
Citations 80
Followers 0
Related Specialties
Chemistry
Oncology
Biology
Top 10 Co-Authors
Ismail A Abdelhamid
Fatma M Saleh
Magda F Mohamed
Farid M Sroor
Enas M Awad
Nada S Ibrahim
Mohamed A Mohamed Teleb
Karima F Mahrous
Yasmin Sh Mohamed
Nesma Abdelaal
Published In
Molecules
Anticancer Agents Med Chem
RSC Adv
Mini Rev Med Chem
Naunyn Schmiedebergs Arch Pharmacol
Affiliations
Soon will be listed here.
Recent Articles
1.
Utility of 6-aza-2-thiothymine in the synthesis of novel [1,2,4]triazolo[4,3-][1,2,4]triazin-7-one derivatives: synthesis, structure elucidation, molecular docking and anti-lung cancer activity
Kamel M, Sroor F, Mahmoud K, Shafey H, Hassaneen H, Vendier L
RSC Adv . 2025 Feb; 15(8):6015-6031. PMID: 40013064
Using 6-aza-2-thiothymine (ATT) as a suitable precursor, a novel series of [1,2,4]triazolo[4,3-][1,2,4]triazin-7-one derivatives (7a-j) was prepared by refluxing 6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2)-one (3) with hydrazonoyl halides (1a-j) in chloroform in the presence of...
2.
Design, synthesis, and in-Silco ADME prediction of some novel bis(1,3,4-thiadiazoles) encapsulated lipid-chitosan nano capsule decorative with magnetic nanoparticles and their potential anti-helicobacter pylori activity
Salem M, Elwahy A, Hassaneen H, Selim A, Mohammed H, Hashem H, et al.
Int J Biol Macromol . 2025 Jan; 296:139746. PMID: 39798735
Helicobacter pylori (H. pylori) is an extremely prevalent human pathogen globally that leads to severe illnesses. Sadly, the worldwide issue of H. pylori's resistance to antimicrobial medications persists. In this...
3.
Design, in silico studies and biological evaluation of novel chalcones tethered triazolo[3,4-a]isoquinoline as EGFR inhibitors targeting resistance in non-small cell lung cancer
Abdelaal N, Ragheb M, Hassaneen H, Elzayat E, Abdelhamid I
Sci Rep . 2024 Nov; 14(1):26647. PMID: 39496648
A novel series of six [1,2,4]triazolo[3,4-a]isoquinolin-3-yl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)prop-2-en-1-ones (3a-3f) was designed and synthesized. They were characterized based on spectral and elemental analyses. In silico studies were also committed to provide insights and...
4.
Design, synthesis and potent anti-pancreatic cancer activity of new pyrazole derivatives bearing chalcone, thiazole and thiadiazole moieties: gene expression, DNA fragmentation, cell cycle arrest and SAR
Kamel M, Sroor F, Hanafy M, Mahrous K, Hassaneen H
RSC Adv . 2024 Aug; 14(37):26954-26970. PMID: 39193301
Less than 5% of pancreatic cancer patients survive for more than five years after diagnosis. Therefore, there is an urgent need for novel therapeutic drugs to treat pancreatic cancer. Herein,...
5.
Synthesis, anticancer evaluation of novel hybrid pyrazole-based chalcones, molecular docking, DNA fragmentation, and gene expression: studies
Yasser N, Sroor F, El-Shorbagy H, Eissa S, Hassaneen H, Abdelhamid I
RSC Adv . 2024 Jul; 14(30):21859-21873. PMID: 38984258
A unique series of pyrazolyl-chalcone derivatives was synthesized the method of Claisen-Schmidt condensation. The desired chalcone derivatives 7a-d and 9a-f were obtained in good yields by reacting the 4-acetyl-5-thiophene-pyrazole with...
6.
Evaluation of Pyrazolyl-Indolizine Derivatives as Antimicrobial Agents: Synthesis, In vitro, In silico ADMET and Molecular Docking Studies
Mukhtar S, Sroor F, Hafez T, Abdelraof M, El-Sayed A, Laboud Y, et al.
Chem Biodivers . 2024 May; 21(8):e202400825. PMID: 38802323
Herein, we report analogues of s-indacene by the synthesis of novel indolizine derivatives. Using chloroform as an appropriate solvent, sixteen derivatives of pyrazolyl-indolizine (4--19) were prepared by the reaction of...
7.
Novel Tetrahydro-[1,2,4]triazolo[3,4-]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis
Darwish M, Moustafa A, Youssef A, Mansour M, Yousef A, El Omri A, et al.
Molecules . 2023 Apr; 28(8). PMID: 37110575
Chalcones are interesting anticancer drug candidates which have attracted much interest due to their unique structure and their extensive biological activity. Various functional modifications in chalcones have been reported, along...
8.
Newly Synthesized Arylazo Derivatives Induce Apoptosis and G2/M Cell Cycle Arrest With Molecular Docking Validation in Human Cancer Cell Lines
Laboud Y, Hassan N, Hassaneen H, Hassaneen H, Saleh F, Mohamed Teleb M
Anticancer Agents Med Chem . 2023 Feb; 23(10):1192-1203. PMID: 36744691
Objective: We reported herein the synthesis of novel arylazo derivatives 3a-e incorporating isoquinoline moiety. Methods: A coupling reaction of 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetonitrile 1 with diazotized heterocyclic amines 2 in ethanol in the...
9.
Novel eco-friendly [1,2,4]triazolo[3,4-a]isoquinoline chalcone derivatives efficiency against fungal deterioration of ancient Egyptian mummy cartonnage, Egypt
Geweely N, Soliman M, Ali R, Hassaneen H, Abdelhamid I
Arch Microbiol . 2023 Jan; 205(2):57. PMID: 36609727
Fungal deterioration is one of the major factors that significantly contribute to mummy cartonnage damage. Isolation and molecular identification of thirteen fungal species contributing to the deterioration of ancient Egyptian...
10.
Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)
Mohamed M, Ibrahim N, Saddiq A, Almaghrabi O, E Al-Hazemi M, Hassaneen H, et al.
Naunyn Schmiedebergs Arch Pharmacol . 2022 Dec; 396(4):719-736. PMID: 36469109
A new chalcone series has been developed that may be useful in the treatment of lung cancer. The new series was confirmed by the different spectral tools. MTT assay was...