Haike Antelmann
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Explore the profile of Haike Antelmann including associated specialties, affiliations and a list of published articles.
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121
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3792
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Recent Articles
1.
Fatykhova D, Fritsch V, Siebert K, Methling K, Lalk M, Busche T, et al.
Eur Respir J
. 2024 Sep;
64(6).
PMID: 39231629
is the most common causative agent of community-acquired pneumonia worldwide. A key pathogenic mechanism that exacerbates severity of disease is the disruption of the alveolar-capillary barrier. However, the specific virulence...
2.
Van Loi V, Busche T, Schnaufer F, Kalinowski J, Antelmann H
Microbiol Spectr
. 2023 Nov;
11(6):e0325223.
PMID: 37930020
colonizes the skin and the airways but can also lead to life-threatening systemic and chronic infections. During colonization and phagocytosis by immune cells, encounters the thiol-reactive oxidant HOSCN. The understanding...
3.
Van Loi V, Busche T, Kuropka B, Muller S, Methling K, Lalk M, et al.
Free Radic Biol Med
. 2023 Oct;
208:859-876.
PMID: 37793500
Staphylococcus aureus is a major pathogen, which has to defend against reactive oxygen and electrophilic species encountered during infections. Activated macrophages produce the immunometabolite itaconate as potent electrophile and antimicrobial...
4.
Shearer H, Loi V, Weiland P, Bange G, Altegoer F, Hampton M, et al.
Mol Microbiol
. 2023 Feb;
119(4):456-470.
PMID: 36779383
The major pathogen Staphylococcus aureus has to cope with host-derived oxidative stress to cause infections in humans. Here, we report that S. aureus tolerates high concentrations of hypothiocyanous acid (HOSCN),...
5.
Fritsch V, Linzner N, Busche T, Said N, Weise C, Kalinowski J, et al.
Mol Microbiol
. 2022 Nov;
119(2):191-207.
PMID: 36349475
Streptococcus pneumoniae has to cope with the strong oxidant hypochlorous acid (HOCl), during host-pathogen interactions. Thus, we analyzed the global gene expression profile of S. pneumoniae D39 towards HOCl stress....
6.
Fritsch V, Van Loi V, Kuropka B, Gruhlke M, Weise C, Antelmann H
Antioxid Redox Signal
. 2022 Oct;
38(13-15):877-895.
PMID: 36242097
The MarR/DUF24-family QsrR and YodB repressors control quinone detoxification pathways in and . In , the QsrR regulon also confers resistance to antimicrobial compounds with quinone-like elements, such as rifampicin,...
7.
Linzner N, Van Loi V, Antelmann H
Antioxidants (Basel)
. 2022 Sep;
11(9).
PMID: 36139867
has to cope with oxidative stress during infections. In this study, was found to be resistant to 100 mM HO during aerobic growth. While KatA was essential for this high...
8.
Ashby L, Springer R, Van Loi V, Antelmann H, Hampton M, Kettle A, et al.
J Leukoc Biol
. 2022 May;
112(4):591-605.
PMID: 35621076
Targeting immune evasion tactics of pathogenic bacteria may hold the key to treating recalcitrant bacterial infections. Staphylococcus aureus produces bacillithiol (BSH), its major low-molecular-weight thiol, which is thought to protect...
9.
Mosbauer K, Fritsch V, Adrian L, Bernhardt J, Gruhlke M, Slusarenko A, et al.
Front Microbiol
. 2021 Nov;
12:746795.
PMID: 34777295
Allicin (diallyl thiosulfinate) is the major thiol-reactive organosulfur compound produced by garlic plants () upon tissue damage. Allicin exerts its strong antimicrobial activity against bacteria and fungi via -thioallylation of...
10.
Van Loi V, Busche T, Fritsch V, Weise C, Gruhlke M, Slusarenko A, et al.
Free Radic Biol Med
. 2021 Oct;
177:120-131.
PMID: 34678418
Staphylococcus aureus has to cope with oxidative and electrophile stress during host-pathogen interactions. The TetR-family repressor GbaA was shown to sense electrophiles, such as N-ethylmaleimide (NEM) via monothiol mechanisms of...