Hagen U Tilgner
Overview
Explore the profile of Hagen U Tilgner including associated specialties, affiliations and a list of published articles.
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22
Citations
892
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Recent Articles
1.
Sehgal P, Naqvi A, Higgins M, Liu J, Harvey K, Jarroux J, et al.
bioRxiv
. 2025 Jan;
PMID: 39868324
Statement Of Significance: Existing targets for chimeric antigen receptors (CAR)-armed T cells are often shared by CNS tumors and normal tissues, creating the potential for on-target/off-tumor toxicities. Here we demonstrate...
2.
Belchikov N, Hsu J, Li X, Jarroux J, Hu W, Joglekar A, et al.
Genome Res
. 2024 Nov;
34(11):1735-1746.
PMID: 39567235
RNA isoform diversity, produced via alternative splicing, and alternative usage of transcription start and poly(A) sites, results in varied transcripts being derived from the same gene. Distinct isoforms can play...
3.
Biegler M, Belay K, Wang W, Szialta C, Collier P, Luo J, et al.
Dev Biol
. 2024 Aug;
517:73-90.
PMID: 39214328
The diversity of germ cell developmental strategies has been well documented across many vertebrate clades. However, much of our understanding of avian primordial germ cell (PGC) specification and differentiation has...
4.
Gong B, Li D, Labaj P, Pan B, Novoradovskaya N, Thierry-Mieg D, et al.
Sci Data
. 2024 Aug;
11(1):892.
PMID: 39152166
Next-generation sequencing (NGS) has revolutionized genomic research by enabling high-throughput, cost-effective genome and transcriptome sequencing accelerating personalized medicine for complex diseases, including cancer. Whole genome/transcriptome sequencing (WGS/WTS) provides comprehensive insights,...
5.
Ament S, Campbell R, Lobo M, Receveur J, Agrawal K, Borjabad A, et al.
Mol Psychiatry
. 2024 Jun;
29(12):3950-3961.
PMID: 38879719
Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with SUD, but also surrounding families and communities. One...
6.
Pardo-Palacios F, Wang D, Reese F, Diekhans M, Carbonell-Sala S, Williams B, et al.
Nat Methods
. 2024 Jun;
21(7):1349-1363.
PMID: 38849569
The Long-read RNA-Seq Genome Annotation Assessment Project Consortium was formed to evaluate the effectiveness of long-read approaches for transcriptome analysis. Using different protocols and sequencing platforms, the consortium generated over...
7.
Joglekar A, Hu W, Zhang B, Narykov O, Diekhans M, Marrocco J, et al.
Nat Neurosci
. 2024 Apr;
27(6):1051-1063.
PMID: 38594596
RNA isoforms influence cell identity and function. However, a comprehensive brain isoform map was lacking. We analyze single-cell RNA isoforms across brain regions, cell subtypes, developmental time points and species....
8.
Hu W, Foord C, Hsu J, Fan L, Corley M, Bhatia T, et al.
bioRxiv
. 2024 Mar;
PMID: 38464236
Multimodal measurements have become widespread in genomics, however measuring open chromatin accessibility and splicing simultaneously in frozen brain tissues remains unconquered. Hence, we devised Single-Cell-ISOform-RNA sequencing coupled with the Assay-for-Transposase-Accessible-Chromatin...
9.
Pardo-Palacios F, Wang D, Reese F, Diekhans M, Carbonell-Sala S, Williams B, et al.
bioRxiv
. 2023 Aug;
PMID: 37546854
The Long-read RNA-Seq Genome Annotation Assessment Project (LRGASP) Consortium was formed to evaluate the effectiveness of long-read approaches for transcriptome analysis. The consortium generated over 427 million long-read sequences from...
10.
Joglekar A, Foord C, Jarroux J, Pollard S, Tilgner H
Transcription
. 2023 Jun;
14(3-5):92-104.
PMID: 37314295
The profiling of gene expression patterns to glean biological insights from single cells has become commonplace over the last few years. However, this approach overlooks the transcript contents that can...