Habib Zaghouani
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Explore the profile of Habib Zaghouani including associated specialties, affiliations and a list of published articles.
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51
Citations
1264
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Recent Articles
1.
Cattin-Roy A, Laffey K, Le L, Schrum A, Zaghouani H
J Clin Invest
. 2024 Dec;
134(23).
PMID: 39621313
Type 1 diabetes (T1D) develops spontaneously despite functional antigen presentation machinery in the thymus and a perceptible central tolerance process. We found that intrathymic enrichment with IL-4 fine tunes signaling...
2.
Chen Z, Castro D, Gupta S, Phalke S, Manni M, Rivera-Correa J, et al.
Arthritis Rheumatol
. 2022 Apr;
74(9):1544-1555.
PMID: 35438841
Objective: Age-associated/autoimmune B cells (ABCs) are an emerging B cell subset with aberrant expansion in systemic lupus erythematosus. ABC generation and differentiation exhibit marked sexual dimorphism, and Toll-like receptor 7...
3.
Ukah T, Cattin-Roy A, Davis G, Zaghouani H
Cell Immunol
. 2021 Apr;
364:104360.
PMID: 33866285
Ig-GAD2, an antigen-specific immune modulator, requires bone marrow (BM) cell transfer in order to restore beta (β)-cell formation and induce recovery from established type 1 diabetes (T1D). The BM cells...
4.
Zaghouani H, Miller M
Crit Rev Immunol
. 2021 Jan;
40(5):407-411.
PMID: 33463951
This brief review is written in memory of Eli Sercarz, a colleague who among many achievements, pioneered and revitalized early-life immunity, a field that is of high relevance to child...
5.
Barik S, Cattin-Roy A, Ukah T, Miller M, Teixeiro E, Zaghouani H
J Immunol
. 2020 Sep;
205(8):2039-2045.
PMID: 32917785
Early thymic progenitors (ETPs) are bone marrow-derived hematopoietic stem cells that remain multipotent and give rise to a variety of lineage-specific cells. Recently, we discovered a subset of murine ETPs...
6.
Miller M, Barik S, Cattin-Roy A, Ukah T, Hoeman C, Zaghouani H
J Immunol
. 2019 Apr;
202(11):3173-3186.
PMID: 30996000
Early life immune responses are deficient in Th1 lymphocytes that compromise neonatal vaccination. We found that IL-4 and IL-13 engage a developmentally expressed IL-4Rα/IL-13Rα1 heteroreceptor to endow IFN regulatory factor...
7.
Barik S, Cattin-Roy A, Miller M, Ukah T, Zaghouani H
J Immunol
. 2018 Oct;
201(10):2947-2958.
PMID: 30291166
Recently we reported that IL-4 and IL-13 signaling in murine early thymic progenitors (ETPs) expressing the heteroreceptor (HR) comprising IL-4 receptor α (IL-4Rα) and IL-13 receptor α 1 (IL-13Rα1) activate...
8.
Barik S, Miller M, Cattin-Roy A, Ukah T, Zaghouani H
Cell Immunol
. 2018 Jun;
331:130-136.
PMID: 29929727
IL-13 receptor alpha 1 (IL-13Rα1) associates with IL-4Rα to form a functional IL-4Rα/IL-13Rα1 heteroreceptor (HR) through which both IL-4 and IL-13 signal. Recently, HR expression was associated with the development...
9.
Barik S, Miller M, Cattin-Roy A, Ukah T, Chen W, Zaghouani H
J Immunol
. 2017 Sep;
199(8):2767-2776.
PMID: 28893952
Early thymic progenitors (ETPs) are endowed with diverse potencies and can give rise to myeloid and lymphoid lineage progenitors. How the thymic environment guides ETP commitment and maturation toward a...
10.
Barik S, Ellis J, Cascio J, Miller M, Ukah T, Cattin-Roy A, et al.
J Immunol
. 2017 Aug;
199(7):2236-2248.
PMID: 28801358
IL-4 and IL-13 have been defined as anti-inflammatory cytokines that can counter myelin-reactive T cells and modulate experimental allergic encephalomyelitis. However, it is not known whether endogenous IL-4 and IL-13...