H W Sharma
Overview
Explore the profile of H W Sharma including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
598
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Recent Articles
1.
Ramakrishnan S, Sharma H, Farris A, Kaufman K, Harley J, Collins K, et al.
Proc Natl Acad Sci U S A
. 1997 Sep;
94(19):10075-9.
PMID: 9294165
Telomerase, a ribonucleoprotein complex, adds hexameric repeats called "telomeres" to the growing ends of chromosomal DNA. Characterization of mammalian telomerase has been elusive because of its low level of expression....
2.
Hsiao R, Sharma H, Ramakrishnan S, KEITH E, Narayanan R
Anticancer Res
. 1997 Mar;
17(2A):827-32.
PMID: 9137415
Telomerase, a ribonucleoprotein complex, adds hexameric repeats of 5' T T A G G G 3' to the ends of chromosomes called telomeres. Telomerase activity is present in germ cells...
3.
Zhu X, Kumar R, Mandal M, Sharma N, Sharma H, Dhingra U, et al.
Proc Natl Acad Sci U S A
. 1996 Jun;
93(12):6091-5.
PMID: 8650224
Telomerase is a ribonucleoprotein complex that is thought to add telomeric repeats onto the ends of chromosomes during the replicative phase of the cell cycle. We tested this hypothesis by...
4.
Sharma H, Narayanan R
Anticancer Res
. 1996 Mar;
16(2):589-96.
PMID: 8687102
The NF-kappaB transcription factor complex is a pleiotropic activator that participates in the induction of a wide variety of cellular and viral genes. The active complex is composed of two...
5.
Khaled Z, Benimetskaya L, Zeltser R, Khan T, Sharma H, Narayanan R, et al.
Nucleic Acids Res
. 1996 Feb;
24(4):737-45.
PMID: 8604318
Phosphorothioate oligodeoxynucleotides complementary to the p65 (Rel A) subunit of the NF-kappaB nuclear transcriptional regulatory factor have been suggested to be sequence specific blockers of cellular adhesion. We studied the...
6.
Sharma H, Hsiao R, Narayanan R
Antisense Nucleic Acid Drug Dev
. 1996 Jan;
6(1):3-7.
PMID: 8783790
Inhibition of gene expression by phosphorothioate oligomers is complex and involves specific and nonspecific mechanisms. Oligomers that contain a G-quartet elicit distinct effects in vitro and in vivo that are...
7.
Sharma H, Perez J, Hsiao R, Narayanan R
Anticancer Res
. 1996 Jan;
16(1):61-9.
PMID: 8615671
Antisense inhibition of the RelA subunit of NF-kappa B transcription factor (but not the NFKB1 subunit) causes pronounced inhibition of tumor cell growth in vitro and in vivo. Inhibition of...
8.
Sharma H, Maltese J, Zhu X, Kaiser H, Narayanan R
Anticancer Res
. 1996 Jan;
16(1):511-5.
PMID: 8615664
Nature recruited telomerase to compensate for the incomplete replication of chromosomal ends (telomeres). In higher organisms, telomeres are eroded at each cell division. Cancer cells frequently show chromosomal instability resulting...
9.
Sharma H, Sokoloski J, Perez J, Maltese J, Sartorelli A, Stein C, et al.
Proc Natl Acad Sci U S A
. 1995 Dec;
92(26):12343-6.
PMID: 8618897
Telomerase, a ribonucleic acid-protein complex, adds hexameric repeats of 5'-TTAGGG-3' to the ends of mammalian chromosomal DNA (telomeres) to compensate for the progressive loss that occurs with successive rounds of...
10.
Sharma H, Narayanan R
Bioessays
. 1995 Dec;
17(12):1055-63.
PMID: 8634067
Specific inhibition of gene expression by antisense agents provides the basis for rational drug discovery based on molecular targets. Due to the specificity of Watson-Crick base-pair hybridization, antisense oligodeoxynucleotides have...