H U Bryant
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Explore the profile of H U Bryant including associated specialties, affiliations and a list of published articles.
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72
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823
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Recent Articles
1.
Farr T, Carswell H, McCann D, Sato M, Bryant H, Dodge J, et al.
J Neuroendocrinol
. 2008 Jan;
20(3):366-74.
PMID: 18208545
Selective oestrogen receptor modulators (SERMs) may offer improved alternatives to oestrogen as neuroprotectants in experimental stroke. The present study investigated the role of a novel SERM, LY362321, in a rat...
2.
Chintalacharuvu S, Evans G, Shih C, Bryant H, Sandusky G, Zuckerman S
Clin Exp Rheumatol
. 2005 Aug;
23(4):438-46.
PMID: 16095110
Objective: To determine the effects of a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor on macrophage inflammatory processes and in vivo in rat adjuvant arthritis. Methods: GARFT inhibitors, LY309886 (6S-2',5'-thienyl-5, 10-dideazatetrahydrofolic acid)...
3.
Helvering L, Adrian M, Geiser A, Estrem S, Wei T, Huang S, et al.
Biol Reprod
. 2004 Dec;
72(4):830-41.
PMID: 15576828
A detailed analysis of the differential effects of estrogen (E) compared to raloxifene (Ral), a selective estrogen receptor modulator (SERM), following estrogen receptor (ER) binding in gynecological tissues was conducted...
4.
Krishnan V, Bullock H, Yaden B, Liu M, Barr R, Montrose-Rafizadeh C, et al.
Mol Pharmacol
. 2004 Nov;
67(3):744-8.
PMID: 15557561
The nongenotropic ligand estren (Science 298:843-846, 2002) was evaluated for its transcriptional activity mediated by the human androgen receptor (AR). Our results show that estren can bind, translocate, transactivate, and...
5.
MacLeay J, Lehmer E, Enns R, Mallinckrodt C, Bryant H, Turner A
Maturitas
. 2003 Oct;
46(3):231-8.
PMID: 14585527
Objectives: To determine if ovariectomized ewes undergo periodic body temperature rises (hot flashes) similar to women at menopause. Methods: Eighteen mature ewes were assigned to ovariectomy (OVX), ovariectomy+17 beta-estradiol implant...
6.
Silfen S, Ciaccia A, Bryant H
Climacteric
. 2002 Mar;
2(4):268-83.
PMID: 11910661
Selective estrogen receptor modulators (SERMs) are compounds that bind to estrogen receptors and produce estrogen-like (agonist) effects in some tissues and estrogen-blocking (antagonist) effects in other tissues. One of the...
7.
Suh N, Glasebrook A, Palkowitz A, Bryant H, Burris L, Starling J, et al.
Cancer Res
. 2001 Dec;
61(23):8412-5.
PMID: 11731420
Arzoxifene ([6-hydroxy-3-[4-[2-(1-piperidinyl)-ethoxy]phenoxy]-2-(4-methoxyphenyl)]benzo[b]thiophene) is a selective estrogen receptor modulator (SERM) that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density...
8.
Bryant H
Rev Endocr Metab Disord
. 2001 Nov;
2(1):129-38.
PMID: 11704975
Raloxifene possesses a complex pharmacology with tissue-selective estrogen agonist and antagonist effects. At the center of these effects resides the high affinity interaction of raloxifene with the ER. The ability...
9.
Grese T, Adrian M, Phillips D, Shetler P, Short L, Glasebrook A, et al.
J Med Chem
. 2001 Aug;
44(17):2857-60.
PMID: 11495597
Selective estrogen receptor modulators are an emerging class of pharmaceutically important molecules. Many compounds in this class contain an aminoethoxyaryl moiety attached to a polycyclic framework at an asymmetric carbon...
10.
Gaynor J, Monnet E, Selzman C, Parker D, Kaufman L, Bryant H, et al.
J Vet Pharmacol Ther
. 2000 Dec;
23(3):175-9.
PMID: 11110106
Background: Ovariectomized sheep are a useful model of postmenopausal osteoporosis and other postmenopausal conditions. Estrogen may have a protective effect on the coronary arteries in postmenopausal women. The effects of...