H Safayhi
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Explore the profile of H Safayhi including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
792
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Recent Articles
1.
Rall B, Ammon H, Safayhi H
Phytomedicine
. 2012 Dec;
3(1):75-6.
PMID: 23194866
The involvement of human leukocyte elastase (HLE) in several inflammatory processes and the reported inhibitory effect of ursolic acid on HLE has prompted the authors to start investigation on the...
2.
Sailer E, Hoernlein R, Ammon H, Safayhi H
Phytomedicine
. 2012 Dec;
3(1):73-4.
PMID: 23194865
Acetyl-11-keto-β-boswellic acid (AKBA) from Boswellia serrata Roxb. and italics Boswellia carterii Birdw. is the first selective, direct, non-competitive and non-redox-type inhibitor of 5-lipoxygenase, the key enzyme for leukotriene biosynthesis (Safayhi...
3.
Safayhi H, Sailer E, Ammon H
Phytomedicine
. 2012 Dec;
3(1):71-2.
PMID: 23194864
Acetyl-11-keto-β-boswellic acid (AKAB) from Boswellia serrata and B. carterii acts directly on purified 5-lipoxygenase of human blood leukocytes at a selective site for pentacyclic triterpenes that is different from the...
4.
Gupta I, Parihar A, Malhotra P, Gupta S, Ludtke R, Safayhi H, et al.
Planta Med
. 2001 Aug;
67(5):391-5.
PMID: 11488449
Patients studied here suffered from chronic colitis characterized by vague lower abdominal pain, bleeding per rectum with diarrhoea and palpable tender descending and sigmoid colon. The inflammatory process in colitis...
5.
Boden S, Schweizer S, Bertsche T, Dufer M, Drews G, Safayhi H
Mol Pharmacol
. 2001 Jul;
60(2):267-73.
PMID: 11455013
Commercially available extracts from Boswellia serrata resin used as anti-inflammatory drugs or phytonutrients show paradoxical concentration-dependent potentiating and inhibitory actions on 5-lipoxygenase (5-LO) product synthesis in stimulated PMNs. In our...
6.
Krieglstein C, Anthoni C, Rijcken E, Laukotter M, Spiegel H, Boden S, et al.
Int J Colorectal Dis
. 2001 May;
16(2):88-95.
PMID: 11355324
The gum resin extract from Boswellia serrata (H15), an herbal product, was recently shown to have positive therapeutic effects in inflammatory bowel disease (IBD). However, the mechanisms and constituents responsible...
7.
Schweizer S, Eichele K, Ammon H, Safayhi H
Planta Med
. 2001 Feb;
66(8):781-2.
PMID: 11199146
The pentacyclic triterpenoid 3-acetyl-11-keto-beta-boswellic acid (AKBA) from the resin of Boswellia spec. is a potent inhibitor of 5-lipoxygenase (5-LO). We noticed discrepancies in the nomenclature and stereochemistry of the 3-acetoxy...
8.
Boden S, Bertsche T, Ammon H, Safayhi H
Int J Biochem Cell Biol
. 2000 Nov;
32(10):1069-74.
PMID: 11091139
In order to elucidate the role of mitogen-activated protein kinase kinase (MEK-1/2) in 5-lipoxygenase (5-LO) activation we studied the N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced 5-LO translocation in human blood neutrophils (PMNs). In non-primed,...
9.
Evans J, Lee J, Park Y, Jeun S, Harwalkar J, Safayhi H, et al.
Neurosurg Clin N Am
. 2000 Nov;
11(4):717-33.
PMID: 11082181
No abstract available.
10.
Schweizer S, von Brocke A, Boden S, Bayer E, Ammon H, Safayhi H
J Nat Prod
. 2000 Sep;
63(8):1058-61.
PMID: 10978197
Pentacyclic triterpenes from the 11-keto-boswellic acid series were identified as the active principal ingredients of Boswellia resin, inhibiting the key enzyme of leukotriene biosynthesis, 5-lipoxygenase (5-LO). Of the genuine boswellic...