H P Kiem
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Explore the profile of H P Kiem including associated specialties, affiliations and a list of published articles.
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52
Citations
1145
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Recent Articles
1.
Moffett H, Coon M, Radtke S, Stephan S, McKnight L, Lambert A, et al.
Nat Commun
. 2017 Sep;
8(1):389.
PMID: 28855514
Therapies based on immune cells have been applied for diseases ranging from cancer to diabetes. However, the viral and electroporation methods used to create cytoreagents are complex and expensive. Consequently,...
2.
Thakar M, Bonfim C, Sandmaier B, ODonnell P, Ribeiro L, Gooley T, et al.
Pediatr Hematol Oncol
. 2012 Jul;
29(6):568-78.
PMID: 22839094
Allogeneic hematopoietic cell transplantation (HCT) is the only known cure for patients with Fanconi anemia (FA) who develop aplasia or leukemia. However, transplant regimens typically contain high-dose alkylators, which are...
3.
Murnane R, Zhang X, Hukkanen R, Vogel K, Kelley S, Kiem H
Vet Pathol
. 2010 Sep;
48(5):999-1001.
PMID: 20870955
Gammaretroviral vectors are an efficient means to effect gene therapy. However, genotoxicity from insertion at nonrandom sites can confer a competitive advantage to transduced cells, resulting in clonal proliferation or...
4.
Watts K, Beard B, Wood B, Kiem H
J Med Primatol
. 2009 Jul;
38(6):425-32.
PMID: 19638102
Purpose: We used total body irradiation (TBI) as conditioning for cord blood transplantation studies in pigtailed macaques. In these studies, different doses of TBI were explored to obtain optimal myelosuppression...
5.
Zanis-Neto J, Flowers M, Medeiros C, Bitencourt M, Bonfim C, Setubal D, et al.
Br J Haematol
. 2005 Jun;
130(1):99-106.
PMID: 15982351
Allogeneic haematopoietic cell transplantation (HCT) is effective therapy for Fanconi anaemia (FA). FA patients do not tolerate conditioning with 200 mg/kg of cyclophosphamide (Cy), typically used in aplastic anaemia. We...
6.
Purton L, Morris J, Bernstein I, Collins S, Kiem H
J Hematother Stem Cell Res
. 2002 Jan;
10(6):815-25.
PMID: 11798508
A major limiting factor in achieving high levels of gene transfer into hematopoietic stem cells is the ability to retain significant repopulating activity of the stem cells during the ex...
7.
Bruno B, Goerner M, Nash R, Storb R, Kiem H, McSweeney P
Biol Blood Marrow Transplant
. 2002 Jan;
7(10):543-51.
PMID: 11760086
Human CD34+ cells have been shown to retain long-term hematopoietic engrafting potential in preclinical and clinical studies. However, recent studies of human and murine CD34- stem cells suggest that these...
8.
Georges G, Storb R, Bruno B, BRODIE S, Thompson J, Taranova A, et al.
Blood
. 2001 Nov;
98(12):3447-55.
PMID: 11719387
Genetically modified donor T cells with an inducible "suicide" gene have the potential to improve the safety and availability of allogeneic hematopoietic stem cell transplantation by enhancing engraftment and permitting...
9.
Goerner M, Horn P, Peterson L, Kurre P, Storb R, Rasko J, et al.
Blood
. 2001 Sep;
98(7):2065-70.
PMID: 11567991
Previous studies have shown that the choice of envelope protein (pseudotype) can have a significant effect on the efficiency of retroviral gene transfer into hematopoietic stem cells. This study used...
10.
Feinstein L, Sandmaier B, Maloney D, McSweeney P, Maris M, Flowers C, et al.
Ann N Y Acad Sci
. 2001 Jul;
938:328-37; discussion 337-9.
PMID: 11458521
Conventional allografting produces considerable regimen-related toxicities that generally limit this treatment to patients younger than 55 years and in otherwise good medical condition. T cell-mediated graft-versus-tumor (GVT) effects are known...