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H O Goyal

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Recent Articles
1.
Simon L, Avery L, Braden T, Williams C, Okumu L, Williams J, et al.
Int J Androl . 2011 Dec; 35(3):364-76. PMID: 22150386
We previously reported that oestrogen exposure in neonatal rats induced permanent infertility and malformed penis characterized by fat accumulation, which replaced most of the smooth muscle cells and cavernous spaces...
2.
Goyal H, Braden T, Williams C, Williams J
Biol Reprod . 2009 May; 81(3):507-16. PMID: 19420389
This study tested the hypothesis that the estrogen receptor (ESR) pathway, androgen receptor (AR) pathway, or both mediate estrogen-induced developmental penile disorders. Rat pups received diethylstilbestrol (DES), with or without...
3.
Goyal H, Braden T, Williams C, Williams J
Reproduction . 2007 Jul; 134(2):199-208. PMID: 17660230
In this review, we report permanent dysmorphogenesis of the penis and loss of fertility in adult rats treated neonatally with estrogen. Specifically, we report replacement of smooth muscle cells and...
4.
Goyal H, Braden T, Cooke P, Szewczykowski M, Williams C, Dalvi P, et al.
Reproduction . 2007 Jul; 133(5):1057-67. PMID: 17616734
Previously, we reported an association between estrogen receptor-alpha (ERalpha) upregulation and detrimental effects of neonatal diethylstilbestrol (DES) exposure in the rat penis. The objective of this study was to employ...
5.
Goyal H, Braden T, Williams C, Dalvi P, Mansour M, Williams J
Toxicol Sci . 2005 Jun; 87(1):242-54. PMID: 15976194
We previously reported that diethylstilbestrol (DES) or estradiol valerate (EV) exposure at a dose of 0.10-0.12 mg/kg, or higher, per day, on alternate days, from postnatal days 2-12, resulted in...
6.
Goyal H, Braden T, Williams C, Dalvi P, Williams J, Srivastava K
Reprod Toxicol . 2004 Mar; 18(2):265-74. PMID: 15019723
The research objectives are to determine whether estrogen-induced infertility is associated with abnormal morphology of the penis and if morphological alterations can be reversed by testosterone (T). Male pups received...
7.
Goyal H, Braden T, Williams C, Dalvi P, Mansour M, Mansour M, et al.
Biol Reprod . 2004 Jan; 70(5):1504-17. PMID: 14749301
Objectives of the study were to determine developmental changes in morphology and expression of androgen receptor (AR) and estrogen receptor (ER)alpha in the body of the rat penis exposed neonatally...
8.
Goyal H, Robateau A, Braden T, Williams C, Srivastava K, Ali K
Biol Reprod . 2003 Feb; 68(6):2081-91. PMID: 12606459
The effects of neonatal exposure to different doses of diethylstilbestrol (DES) on the reproductive functions of male rats at adulthood were evaluated. Sprague-Dawley rats (5-8/group) received sc injections of 25...
9.
Mansour M, Machen M, Tarleton B, Wiley A, Wower J, Bartol F, et al.
Biol Reprod . 2001 Apr; 64(5):1432-8. PMID: 11319148
The fact that male estrogen receptor alpha (ERalpha) knockout mice are infertile indicates a role for this receptor in male reproduction. Here, objectives were to evaluate ERalpha expression in male...
10.
Goyal H, Braden T, Mansour M, Williams C, Kamaleldin A, Srivastava K
Biol Reprod . 2001 Feb; 64(3):927-34. PMID: 11207210
In this study, we characterized estrogenic effects of diethylstilbestrol (DES) on reproductive parameters in male rats to identify a minimal dose level that alters epididymal and sperm functions but has...