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H K Wasner

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1.
Wasner H, Muller G, Eckel J
Exp Clin Endocrinol Diabetes . 2003 Oct; 111(6):358-63. PMID: 14520603
Though insulin signalling is thought by many groups to function without second messenger action, others have provided evidence for the existence and action of such regulators. Chemically quite different compounds,...
2.
Shashkin P, Wasner H, Ortmeyer H, Hansen B
Diabetes Metab Res Rev . 2001 Sep; 17(4):273-84. PMID: 11544611
Insulin induces a broad spectrum of effects over a wide time interval. It also stimulates the phosphorylation of some cellular proteins, while decreasing the state of phosphorylation of others. These...
3.
Shashkin P, Meckmongkol T, Wasner H, Hansen B, Ortmeyer H
J Basic Clin Physiol Pharmacol . 2001 Jun; 12(1):1-18. PMID: 11414504
Prostaglandylinositol cyclic phosphate (cPIP), functionally a cAMP antagonist, is a novel, low-molecular weight mediator of insulin action. Both essential hypertension and type 2 diabetes may be associated with a reduction...
4.
Gypakis A, Wasner H
Biol Chem . 2001 Jan; 381(11):1139-41. PMID: 11154073
It has been suggested that downstream signaling from the insulin receptor to the level of the protein kinases and protein phosphatases is accomplished by prosta-glandylinositol cyclic phosphate (cyclic PIP), a...
5.
Weber S, Lemoine H, Wasner H
Biol Chem . 2000 Aug; 381(5-6):525-9. PMID: 10937886
Inhibition of prostaglandin synthesis by the drug indomethacin suppresses the synthesis of the cyclic AMP antagonist, prostaglandylinositol cyclic phosphate (cyclic PIP), and leads to a metabolic state comparable to type...
6.
Wasner H, Gebel M, Hucken S, Schaefer M, Kincses M
Biol Chem . 2000 Apr; 381(2):145-53. PMID: 10746746
The biosynthesis of the functional, endogenous cyclic AMP antagonist, prostaglandylinositol cyclic phosphate (cyclic PIP) is performed by the plasma membrane-bound enzyme cyclic PIP synthase, which combines prostaglandin E (PGE) and...
7.
Kassner A, Lessmann M, Wasner H
Biol Chem . 1999 Mar; 380(1):85-8. PMID: 10064141
The cAMP antagonist, prostaglandylinositol cyclic phosphate (cyclic PIP), is synthesized from prostaglandin E and activated inositol phosphate. From various tissues only that amount of cyclic PIP can be isolated that...
8.
Kaiser A, Wasner H, Spindler K
Biol Chem . 1998 Aug; 379(6):727-30. PMID: 9687023
The cyclic AMP antagonist, prostaglandylinositol cyclic phosphate (cyclic PIP), is synthesized from prostaglandin E (PGE) and activated inositol phosphate (n-IP) in the presence of ATP by an enzyme of rat...
9.
Wasner H, Salge U, Psarakis E, Niktopoulos A
Acta Diabetol . 1998 Feb; 34(4):257-64. PMID: 9451469
Reduced ability or failure to stimulate cyclic adenosinemonophosphate (AMP) synthesis on a second addition of hormone 30 min after a first stimulation was taken as an indirect indication of the...
10.
Wasner H, Lessmann M, Conrad M, Amini H, Psarakis E
Acta Diabetol . 1996 Jul; 33(2):126-38. PMID: 8870815
The endogenous cyclic adenosine monophosphate (AMP) antagonist, cyclic PIP, has been identified as a prostaglandylinositol cyclic phosphate. It inhibits protein kinase A 100% and activates protein serine phosphatase about sevenfold....