H K Manji
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Explore the profile of H K Manji including associated specialties, affiliations and a list of published articles.
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91
Citations
2898
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Recent Articles
1.
Dalgard C, Eidelman O, Jozwik C, Olsen C, Srivastava M, Biswas R, et al.
Transl Psychiatry
. 2017 Feb;
7(2):e1025.
PMID: 28170001
Post-traumatic stress disorder (PTSD) is psychiatric disease, which can occur following exposure to traumatic events. PTSD may be acute or chronic, and can have a waxing and waning course of...
2.
Martinowich K, Jimenez D, Zarate Jr C, Manji H
Mol Psychiatry
. 2013 May;
18(8):856-63.
PMID: 23689537
Available treatments for depression have significant limitations, including low response rates and substantial lag times for response. Reports of rapid antidepressant effects of a number of compounds, including the glutamate...
3.
Manji H, Hsiao J, Risby E, Osman O, Rudorfer M, Potter W
J Psychopharmacol
. 2012 Feb;
6(4):501-8.
PMID: 22291398
We prospectively investigated the effects of a course of electroconvulsive therapy (ECT) on neuroendocrine responses to serotonergic challenge in five depressed patients. Low dose intravenous chlorimipramine (CMI) challenge produced a...
4.
5.
Grossman F, Manji H, Potter W
J Psychopharmacol
. 2012 Feb;
7(1 Suppl):4-18.
PMID: 22290365
During the past decade, results from radioligand studies comparing platelet α(2)-adrenoreceptors in depressed patients and healthy volunteers have been inconsistent, especially when related to the known functional characteristics of these...
6.
Targeting the BH3-interacting domain death agonist to develop mechanistically unique antidepressants
Malkesman O, Austin D, Tragon T, Henter I, Reed J, Pellecchia M, et al.
Mol Psychiatry
. 2011 Jul;
17(8):770-80.
PMID: 21727899
The BH3-interacting domain death agonist (Bid) is a pro-apoptotic member of the B-cell lymphoma-2 (Bcl-2) protein family. Previous studies have shown that stress reduces levels of Bcl-2 in brain regions...
7.
Schloesser R, Lehmann M, Martinowich K, Manji H, Herkenham M
Mol Psychiatry
. 2010 Mar;
15(12):1152-63.
PMID: 20308988
The subgranular zone of the adult hippocampal dentate gyrus contains a pool of neural stem cells that continuously divide and differentiate into functional granule cells. It has been shown that...
8.
Chen G, Henter I, Manji H
Mol Psychiatry
. 2010 Feb;
15(9):883-95.
PMID: 20142820
Bipolar disorder (BPD) is characterized by vulnerability to episodic depression and mania and spontaneous cycling. Because of marked advances in candidate-gene and genome-wide association studies, the list of risk genes...
9.
Shaltiel G, Maeng S, Malkesman O, Pearson B, Schloesser R, Tragon T, et al.
Mol Psychiatry
. 2008 Mar;
13(9):858-72.
PMID: 18332879
The glutamate receptor 6 (GluR6 or GRIK2, one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD), but its function in affective...
10.
Engel S, Creson T, Hao Y, Shen Y, Maeng S, Nekrasova T, et al.
Mol Psychiatry
. 2008 Jan;
14(4):448-61.
PMID: 18227838
The extracellular signal-regulated kinase (ERK) pathway mediates neuronal plasticity in the CNS. The mood stabilizers lithium and valproate activate the ERK pathway in prefrontal cortex and hippocampus and potentiate ERK...