H I Georgescu
Overview
Explore the profile of H I Georgescu including associated specialties, affiliations and a list of published articles.
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57
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1144
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Recent Articles
1.
Del Vecchio M, Georgescu H, McCormack J, Robbins P, Evans C
Arthritis Res
. 2001 Jul;
3(4):259-63.
PMID: 11438045
This report concerns a clinical trial for rheumatoid arthritis (RA), approved by the US National Institutes of Health and the Food and Drug Administration. An amphotropic retrovirus (MFG-IRAP) was used...
2.
Shuler F, Georgescu H, Niyibizi C, Studer R, Mi Z, Johnstone B, et al.
J Orthop Res
. 2000 Oct;
18(4):585-92.
PMID: 11052495
Monolayer cultures of lapine articular chondrocytes were transduced with first-generation adenoviral vectors carrying lacZ or transforming growth factor beta1 genes under the transcriptional control of the human cytomegalovirus early promoter....
3.
Smith P, Shuler F, Georgescu H, Ghivizzani S, Johnstone B, Niyibizi C, et al.
Arthritis Rheum
. 2000 May;
43(5):1156-64.
PMID: 10817570
Objective: To determine whether articular chondrocytes express growth factor genes delivered by adenoviral vectors and whether expression of these genes influences matrix synthesis in the presence and absence of interleukin-1...
4.
Cao M, Stefanovic-Racic M, Georgescu H, Fu F, Evans C
Am J Sports Med
. 2000 Apr;
28(2):176-82.
PMID: 10750993
This study compared the ability of rabbit medial collateral ligament, posterior cruciate ligament, and anterior cruciate ligament tissue to synthesize nitric oxide, and determined its effects on matrix synthesis, an...
5.
Weiss K, Georgescu H, Gollin S, Kang R, Evans C
Inflamm Res
. 2000 Feb;
48 Suppl 2:S132-3.
PMID: 10667850
No abstract available.
6.
Baltzer A, Whalen J, Muzzonegro T, Georgescu H, Robbins P, Evans C
Z Rheumatol
. 1999 Jul;
58(2):88-94.
PMID: 10408069
Objectives: The involvement of cytokines in degeneration and inflammation of human tissue is well established. Interleukin-1 (IL-1) is a major agent in the pathophysiology of periarticular bone resorption in rheumatoid...
7.
Hildebrand K, Deie M, Allen C, Smith D, Georgescu H, Evans C, et al.
J Orthop Res
. 1999 Mar;
17(1):37-42.
PMID: 10073645
Gene therapy is a technique that may offer advantages over current methods of cytokine delivery to ligaments. To determine if implanted genes could be expressed in normal and injured knee...
8.
Studer R, Georgescu H, Miller L, Evans C
Arthritis Rheum
. 1999 Feb;
42(2):248-57.
PMID: 10025918
Objective: Nitric oxide (NO) is generated copiously by articular chondrocytes activated by interleukin-1beta (IL-1beta). If NO production is blocked, much of the IL-1beta inhibition of proteoglycan synthesis is prevented. We...
9.
Cao M, Stefanovic-Racic M, Georgescu H, Miller L, Evans C
J Orthop Res
. 1998 May;
16(1):104-11.
PMID: 9565081
Slices of lapine meniscus produced large amounts of nitric oxide after stimulation with interleukin-1, tumor necrosis factor alpha, or a mixture of lapine synovial cytokines known as chondrocyte-activating factors. Monolayer...
10.
Ghivizzani S, Kang R, Georgescu H, Lechman E, Jaffurs D, Engle J, et al.
J Immunol
. 1997 Oct;
159(7):3604-12.
PMID: 9317160
To investigate the pathophysiologic effects of chronically elevated intra-articular levels of IL-1 beta, we used an ex vivo gene transfer method to deliver and express human IL-1 beta (hIL-1 beta)...