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» Authors » H E Barksby

H E Barksby

Explore the profile of H E Barksby including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 305
Followers 0
Related Specialties
Rheumatology
Allergy & Immunology
Dentistry
Top 10 Co-Authors
A D Rowan
W Hui
T E Cawston
J J Taylor
P M Preshaw
J M Milner
K M Jaedicke
C D Richards
J Middleton
N J Peake
Published In
Arthritis Rheum
Clin Exp Immunol
Ann Rheum Dis
J Periodontal Res
Affiliations
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Recent Articles
1.
Do patients with aggressive periodontitis have evidence of diabetes? A pilot study
Davies R, Jaedicke K, Barksby H, Jitprasertwong P, Al-Shahwani R, Taylor J, et al.
J Periodontal Res . 2011 Jun; 46(6):663-72. PMID: 21679187
Background And Objective: Complex relationships exist between diabetes and periodontal disease. Diabetes is accepted as a risk factor for periodontal disease, and recent evidence supports the existence of a bidirectional...
2.
Differential expression of immunoregulatory genes in monocytes in response to Porphyromonas gingivalis and Escherichia coli lipopolysaccharide
Barksby H, Nile C, Jaedicke K, Taylor J, Preshaw P
Clin Exp Immunol . 2009 May; 156(3):479-87. PMID: 19438601
Porphyromonas gingivalis lipopolysaccharide (LPS) (strain W50) interacts with Toll-like receptor 2 (TLR-2) leading to cytokine expression and inflammation, and thereby plays a key role in the pathogenesis of periodontal disease....
3.
The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders
Barksby H, Lea S, Preshaw P, Taylor J
Clin Exp Immunol . 2007 Jun; 149(2):217-25. PMID: 17590166
Understanding cytokine immunobiology is central to the development of rational therapies for destructive inflammatory diseases such as rheumatoid arthritis (RA) and periodontitis. The classical interleukin-1 (IL-1) family cytokines, IL-1alpha and...
4.
Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis
Barksby H, Milner J, Patterson A, Peake N, Hui W, Robson T, et al.
Arthritis Rheum . 2006 Sep; 54(10):3244-53. PMID: 17009259
Objective: We have previously reported the up-regulation of matrix metalloproteinase 10 (MMP-10) following treatment with the procatabolic stimulus of interleukin-1 (IL-1) and oncostatin M (OSM) in chondrocytes. Although MMP-10 is...
5.
Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes: implications for cartilage destruction and repair
Barksby H, Hui W, Wappler I, Peters H, Milner J, Richards C, et al.
Arthritis Rheum . 2006 Feb; 54(2):540-50. PMID: 16447230
Objective: To identify the genes up-regulated by interleukin-1 (IL-1) in combination with oncostatin M (OSM) in chondrocytes that may be involved in mechanisms of cartilage repair and degradation. Methods: Gene...
6.
Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2
Hui W, Barksby H, Young D, Cawston T, McKie N, Rowan A
Ann Rheum Dis . 2005 May; 64(11):1624-32. PMID: 15883123
Objective: To determine whether oncostatin M (OSM) + tumour necrosis factor alpha (TNFalpha) induces aggrecanase activity in chondrocyte membranes, to determine the effects of transforming growth factor beta1 (TGFbeta1), interleukin...