H D Holtje
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Explore the profile of H D Holtje including associated specialties, affiliations and a list of published articles.
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Articles
63
Citations
112
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Recent Articles
1.
Stahl G, Holtje H
Pharmazie
. 2005 May;
60(4):247-53.
PMID: 15881601
It is known that small changes in the amino acid sequence can change the catalytic activity of cytochromes towards substrates dramatically. With the aim to broaden our knowledge about the...
2.
Adikwu M, Holtje H
Boll Chim Farm
. 2002 Nov;
141(4):279-81.
PMID: 12426815
Various mechanisms are often used toxplain the charge-transfer interactions between various electron donors and acceptors. Commonly accepted mechanisms are those in witch the acceptors forms a weak interaction of the...
3.
Schappach A, Holtje H
Pharmazie
. 2002 Jan;
56(11):835-42.
PMID: 11817165
New methods in treatment of hormone-dependent diseases like prostate or breast cancer have become a major subject in medical and pharmaceutical research. Because of the direct correlation of cancer growth...
4.
Schappach A, Holtje H
Pharmazie
. 2001 Jul;
56(6):435-42.
PMID: 11446160
New methods in treatment of hormone-dependent diseases like prostate or breast cancer have become a major subject in medical and pharmaceutical research. Because of the direct correlation of cancer growth...
5.
Adikwu M, Holtje H
Chem Pharm Bull (Tokyo)
. 2001 Jun;
49(6):669-74.
PMID: 11411514
Various mechanisms are often used to explain the interaction between electron donors and acceptors. Commonly proposed mechanisms are those in which the acceptor interacts with the aromatic pi-systems in the...
6.
Holtje M, Forster T, Brandt B, Engels T, von Rybinski W, Holtje H
Biochim Biophys Acta
. 2001 Mar;
1511(1):156-67.
PMID: 11248214
We report the results of an investigation on stratum corneum lipids, which present the main barrier of the skin. Molecular dynamics simulations, thermal analysis and FTIR measurements were applied. The...
7.
van Hooft P, Holtje H
J Comput Aided Mol Des
. 2000 Dec;
14(8):719-30.
PMID: 11131966
A new method is described for generating all-atom protein structures from Calpha-atom information. The method, which combines both local structural trace alignments and comparative side chain modeling with ab initio...
8.
Gysler A, Kleuser B, Sippl W, Lange K, Holtje H, Korting H
Pharm Res
. 1999 Sep;
16(9):1386-91.
PMID: 10496654
Purpose: To investigate pharmacokinetic differences between the nonhalogenated double ester prednicarbate (PC) and the fluorinated monoester betamethasone 17-valerate (BM17V) their metabolism in human keratinocytes and fibroblasts as well as their...
9.
Lemoine H, Weber H, Derix A, Uhrig U, Holtje H, Mannhold R
Eur J Pharmacol
. 1999 Sep;
378(1):85-97.
PMID: 10478568
To characterize ATP-sensitive channels (K(ATP) channels) benzopyrans with different substituents at position 6 were synthesized as new K(ATP)-activators. Their relaxant potencies were determined in rat aorta and trachea. In aorta,...
10.
Schleifer K, Holtje H
Protein Eng
. 1999 Jan;
11(11):1033-40.
PMID: 9876924
A molecular modelling study was performed in order to investigate the pathologically modified properties of L-type voltage-gated calcium channels caused by the arginine-to-histidine mutation at position 528 (R528H) in segment...