H C Middleton
Overview
Explore the profile of H C Middleton including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
471
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Recent Articles
1.
Middleton H, Coull J, Sahakian B, Robbins T
J Psychopharmacol
. 2012 Feb;
8(1):1-7.
PMID: 22298473
Conventional measures of cardiovascular activity correlate poorly with psychological variables and therefore provide imperfect physiological indices of arousal. We have investigated the effects of clonidine upon the spectral distribution of...
2.
3.
Middleton H
J Psychopharmacol
. 2012 Jan;
5(4):281-5.
PMID: 22282820
5-HT(3) and cholecystokinin receptor antagonists with anxiolytic properties threaten a further round of the 'tranquilizers or treatment' debate. Tricyclic antidepressants have been shown to enhance the effect of exposure therapy...
4.
Rogers R, Blackshaw A, Middleton H, Matthews K, Hawtin K, Crowley C, et al.
Psychopharmacology (Berl)
. 1999 Nov;
146(4):482-91.
PMID: 10550499
Rationale: Altered serotonergic and dopaminergic function have been widely implicated in behavioural disorders associated with impulsivity and risk-taking. However, little research has addressed the specific cognitive consequences of changed monoaminergic...
5.
Rogers R, Owen A, Middleton H, Williams E, Pickard J, Sahakian B, et al.
J Neurosci
. 1999 Oct;
19(20):9029-38.
PMID: 10516320
Patients sustaining lesions of the orbital prefrontal cortex (PFC) exhibit marked impairments in the performance of laboratory-based gambling, or risk-taking, tasks, suggesting that this part of the human PFC contributes...
6.
Middleton H, Sharma A, Agouzoul D, Sahakian B, Robbins T
Psychopharmacology (Berl)
. 1999 Aug;
145(4):401-11.
PMID: 10460317
Several investigations have revealed substantial influences of pharmacological manipulation of central noradrenergic activity upon performance in cognitive tests sensitive to frontal lobe dysfunction. They suggest a significant role for the...
7.
Middleton H, Sharma A, Agouzoul D, Sahakian B, Robbins T
Psychophysiology
. 1999 Aug;
36(5):610-8.
PMID: 10442029
Physiological response stereotypy is a well-established psychophysiological construct. Unfortunately, specifying parameters of tasks that evoke differing physiological responses has proved difficult. We have recorded cardiovascular activity while subjects carried out...
8.
Middleton H
J Psychosom Res
. 1998 Mar;
44(1):121-32.
PMID: 9483469
Panic disorder is a common and disabling condition which frequently leads to excessive reliance upon medical facilities. It is also closely associated with the development of agoraphobia. Medical approaches implicate...
9.
Coull J, Sahakian B, Middleton H, Young A, Park S, McShane R, et al.
Psychopharmacology (Berl)
. 1995 Sep;
121(2):222-30.
PMID: 8545528
As the catecholamines have long been implicated in attentional processes, the present investigation compared the effects of the mixed alpha 1/alpha 2 adrenoceptor agonist clonidine (CLO), the benzodiazepine diazepam (DZP),...
10.
Coull J, Middleton H, Robbins T, Sahakian B
Psychopharmacology (Berl)
. 1995 Aug;
120(3):322-32.
PMID: 8524980
The noradrenergic system has repeatedly been implicated in the mediation of attentional processes. Using a double-blind, placebo-controlled design, the present investigation examines the effects of two doses (1.5 micrograms/kg and...