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H Asao

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Recent Articles
1.
Takeda Y, Kato T, Ito H, Kurota Y, Yamagishi A, Sakurai T, et al.
Clin Exp Immunol . 2016 Aug; 186(3):373-386. PMID: 27569996
Myeloid-derived suppressor cells (MDSCs) have a wide spectrum of immunosuppressive activity; control of these cells is a new target for improving clinical outcomes in cancer patients. MDSCs originate from unusual...
2.
Terada R, Asao H, Iida S
Plant Cell Rep . 2004 Jan; 22(9):653-9. PMID: 14740168
A large-scale transformation procedure handling an adequate number of stable transformants with highly efficient positive-negative selection is a necessary prerequisite to successful gene targeting by homologous recombination, as the integration...
3.
Kunzmann S, Wohlfahrt J, Itoh S, Asao H, Komada M, Akdis C, et al.
FASEB J . 2003 Jan; 17(2):194-202. PMID: 12554698
Transforming growth factor-beta1 (TGF-beta1) is a pluripotent cytokine that controls peripheral T cell tolerance mainly in mucosal immunity. It is secreted by regulatory T cells (Tr /Th3) but also by...
4.
Ishii N, Owada Y, Yamada M, Miura S, Murata K, Asao H, et al.
Mol Cell Biol . 2001 Nov; 21(24):8626-37. PMID: 11713295
AMSH, a molecule that associates with STAM1, is involved in the in vitro cell growth signaling mediated by interleukin 2 and granulocyte-macrophage colony-stimulating factor. To investigate the in vivo functional...
5.
Itoh F, Asao H, Sugamura K, Heldin C, Ten Dijke P, Itoh S
EMBO J . 2001 Aug; 20(15):4132-42. PMID: 11483516
Inhibitory Smads, i.e. Smad6 and Smad7, are potent antagonists of the BMP-Smad pathway by interacting with activated bone morphogenetic protein (BMP) type I receptors and thereby preventing the activation of...
6.
Morita E, Tada K, Chisaka H, Asao H, Sato H, Yaegashi N, et al.
J Virol . 2001 Jul; 75(16):7555-63. PMID: 11462027
Human parvovirus B19 infects specifically erythroid progenitor cells, which causes transient aplastic crises and hemolytic anemias. Here, we demonstrate that erythroblastoid UT7/Epo cells infected with B19 virus fall into growth...
7.
Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster D, et al.
J Immunol . 2001 Jun; 167(1):1-5. PMID: 11418623
The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for IL-4, IL-7, IL-9, and IL-15 as well as IL-2. Here we show that the gamma(c) is...
8.
Kikuchi K, Kawasaki Y, Ishii N, Sasaki Y, Asao H, Takeshita T, et al.
Int Immunol . 2001 May; 13(6):777-83. PMID: 11369705
Gads, a hematopoietic-lineage-specific Grb2 family member, is involved in the signaling mediated by the TCR through its interactions with SLP-76 and LAT. Here, we generated transgenic mice expressing Grf40-dSH2, an...
9.
Miura S, Takeshita T, Asao H, Kimura Y, Murata K, Sasaki Y, et al.
Mol Cell Biol . 2000 Nov; 20(24):9346-55. PMID: 11094085
Smad proteins are effector molecules that transmit signals from the receptors for the transforming growth factor beta (TGF-beta) superfamily to the nucleus; of the Smad proteins, Smad2 and Smad4 are...
10.
Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, et al.
FEBS Lett . 2000 Jul; 477(1-2):55-61. PMID: 10899310
We here cloned a cDNA encoding STAM2, a new member of the STAM family, which contains an SH3 domain and ITAM. STAM2 like STAM1 is associated with Jak2 and Jak3,...