Guy Shpak
Overview
Explore the profile of Guy Shpak including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
256
Followers
0
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Recent Articles
1.
Lendemeijer B, Unkel M, Smeenk H, Mossink B, Hijazi S, Gordillo-Sampedro S, et al.
eNeuro
. 2024 Sep;
11(9).
PMID: 39227152
Astrocytes are essential for the formation and maintenance of neural networks. However, a major technical challenge for investigating astrocyte function and disease-related pathophysiology has been the limited ability to obtain...
2.
Zhang Y, Venkateswaran S, Higuera G, Nath S, Shpak G, Matray J, et al.
Adv Healthc Mater
. 2020 Jan;
9(4):e1901347.
PMID: 31943855
Substrates for neuron culture and implantation are required to be both biocompatible and display surface compositions that support cell attachment, growth, differentiation, and neural activity. Laminin, a naturally occurring extracellular...
3.
Stedehouder J, Brizee D, Shpak G, Kushner S
J Neurosci
. 2018 Mar;
38(15):3631-3642.
PMID: 29507147
Axonal myelination of neocortical pyramidal neurons is modulated dynamically by neuronal activity. Recent studies have shown that a substantial proportion of neocortical myelin content is contributed by fast-spiking, parvalbumin (PV)-positive...
4.
de Vrij F, Bouwkamp C, Gunhanlar N, Shpak G, Lendemeijer B, Baghdadi M, et al.
Mol Psychiatry
. 2018 Jan;
24(5):757-771.
PMID: 29302076
Schizophrenia is highly heritable, yet its underlying pathophysiology remains largely unknown. Among the most well-replicated findings in neurobiological studies of schizophrenia are deficits in myelination and white matter integrity; however,...
5.
Higuera G, Iaffaldano G, Bedar M, Shpak G, Broersen R, Munshi S, et al.
Sci Rep
. 2017 Aug;
7(1):8863.
PMID: 28821816
The directed differentiation of patient-derived induced pluripotent stem cells into cell-type specific neurons has inspired the development of therapeutic discovery for neurodegenerative diseases. Many forms of ataxia result from degeneration...
6.
van Esbroeck A, Janssen A, Cognetta 3rd A, Ogasawara D, Shpak G, van der Kroeg M, et al.
Science
. 2017 Jun;
356(6342):1084-1087.
PMID: 28596366
A recent phase 1 trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 led to the death of one volunteer and produced mild-to-severe neurological symptoms in four others....
7.
Shpak G, Zylbertal A, Wagner S
Front Cell Neurosci
. 2015 Feb;
8:432.
PMID: 25642164
Social interactions between mammalian conspecifics rely heavily on molecular communication via the main and accessory olfactory systems. These two chemosensory systems show high similarity in the organization of information flow...
8.
Shpak G, Zylbertal A, Yarom Y, Wagner S
J Neurosci
. 2012 May;
32(18):6251-62.
PMID: 22553031
Many mammals rely on pheromones for mediating social interactions. Recent studies indicate that both the main olfactory system (MOS) and accessory olfactory system (AOS) detect and process pheromonal stimuli, yet...