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Guy Bottu

Explore the profile of Guy Bottu including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 450
Followers 0
Related Specialties
Biology
Biochemistry
Microbiology
Top 10 Co-Authors
Izortze Santin
Piero Marchetti
Lorella Marselli
Michael Sammeth
Miriam Cnop
Decio L Eizirik
Didier Salmon
Mark I McCarthy
Alexander Botzki
Mariana Igoillo-Esteve
Published In
BMC Bioinformatics
Mol Biochem Parasitol
PLoS Genet
Microbiol Res
Diabetes
Affiliations
Soon will be listed here.
Recent Articles
1.
The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017
Catani J, Smet A, Ysenbaert T, Vuylsteke M, Bottu G, Mathys J, et al.
Elife . 2024 May; 12. PMID: 38805550
Human H3N2 influenza viruses are subject to rapid antigenic evolution which translates into frequent updates of the composition of seasonal influenza vaccines. Despite these updates, the effectiveness of influenza vaccines...
2.
SNPeffect 5.0: large-scale structural phenotyping of protein coding variants extracted from next-generation sequencing data using AlphaFold models
Janssen K, Duran-Romana R, Bottu G, Guharoy M, Botzki A, Rousseau F, et al.
BMC Bioinformatics . 2023 Jul; 24(1):287. PMID: 37464277
Background: Next-generation sequencing technologies yield large numbers of genetic alterations, of which a subset are missense variants that alter an amino acid in the protein product. These variants can have...
3.
Identification and preliminary characterization of a putative C-type lectin receptor-like protein in the T. cruzi tomato lectin endocytic-enriched proteome
Brosson S, Bottu G, Pays E, Bousbata S, Salmon D
Microbiol Res . 2017 Sep; 205:73-79. PMID: 28942847
Trypanosoma cruzi, the etiological agent of the Chagas' disease in Latin America undergoes a complex life cycle involving two hosts, a mammalian host and a reduviid insect vector (triatomine). In...
4.
In vitro metacyclogenesis of Trypanosoma cruzi induced by starvation correlates with a transient adenylyl cyclase stimulation as well as with a constitutive upregulation of adenylyl cyclase expression
Hamedi A, Botelho L, Britto C, Fragoso S, Umaki A, Goldenberg S, et al.
Mol Biochem Parasitol . 2015 Apr; 200(1-2):9-18. PMID: 25912925
The Trypanosoma cruzi adenylyl cyclase (AC) multigene family encodes different isoforms (around 15) sharing a variable large N-terminal domain, which is extracellular and receptor-like, followed by a transmembrane helix and...
5.
RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate
Cnop M, Abdulkarim B, Bottu G, Cunha D, Igoillo-Esteve M, Masini M, et al.
Diabetes . 2014 Jan; 63(6):1978-93. PMID: 24379348
Pancreatic β-cell dysfunction and death are central in the pathogenesis of type 2 diabetes (T2D). Saturated fatty acids cause β-cell failure and contribute to diabetes development in genetically predisposed individuals....
6.
The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines
Eizirik D, Sammeth M, Bouckenooghe T, Bottu G, Sisino G, Igoillo-Esteve M, et al.
PLoS Genet . 2012 Mar; 8(3):e1002552. PMID: 22412385
Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by cytokines released by these cells. Signaling events occurring in...
7.
methBLAST and methPrimerDB: web-tools for PCR based methylation analysis
Pattyn F, Hoebeeck J, Robbrecht P, Michels E, De Paepe A, Bottu G, et al.
BMC Bioinformatics . 2006 Nov; 7:496. PMID: 17094804
Background: DNA methylation plays an important role in development and tumorigenesis by epigenetic modification and silencing of critical genes. The development of PCR-based methylation assays on bisulphite modified DNA heralded...