Guy Bottu
Overview
Explore the profile of Guy Bottu including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
450
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0
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Recent Articles
1.
Catani J, Smet A, Ysenbaert T, Vuylsteke M, Bottu G, Mathys J, et al.
Elife
. 2024 May;
12.
PMID: 38805550
Human H3N2 influenza viruses are subject to rapid antigenic evolution which translates into frequent updates of the composition of seasonal influenza vaccines. Despite these updates, the effectiveness of influenza vaccines...
2.
Janssen K, Duran-Romana R, Bottu G, Guharoy M, Botzki A, Rousseau F, et al.
BMC Bioinformatics
. 2023 Jul;
24(1):287.
PMID: 37464277
Background: Next-generation sequencing technologies yield large numbers of genetic alterations, of which a subset are missense variants that alter an amino acid in the protein product. These variants can have...
3.
Brosson S, Bottu G, Pays E, Bousbata S, Salmon D
Microbiol Res
. 2017 Sep;
205:73-79.
PMID: 28942847
Trypanosoma cruzi, the etiological agent of the Chagas' disease in Latin America undergoes a complex life cycle involving two hosts, a mammalian host and a reduviid insect vector (triatomine). In...
4.
Hamedi A, Botelho L, Britto C, Fragoso S, Umaki A, Goldenberg S, et al.
Mol Biochem Parasitol
. 2015 Apr;
200(1-2):9-18.
PMID: 25912925
The Trypanosoma cruzi adenylyl cyclase (AC) multigene family encodes different isoforms (around 15) sharing a variable large N-terminal domain, which is extracellular and receptor-like, followed by a transmembrane helix and...
5.
Cnop M, Abdulkarim B, Bottu G, Cunha D, Igoillo-Esteve M, Masini M, et al.
Diabetes
. 2014 Jan;
63(6):1978-93.
PMID: 24379348
Pancreatic β-cell dysfunction and death are central in the pathogenesis of type 2 diabetes (T2D). Saturated fatty acids cause β-cell failure and contribute to diabetes development in genetically predisposed individuals....
6.
Eizirik D, Sammeth M, Bouckenooghe T, Bottu G, Sisino G, Igoillo-Esteve M, et al.
PLoS Genet
. 2012 Mar;
8(3):e1002552.
PMID: 22412385
Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by cytokines released by these cells. Signaling events occurring in...
7.
Pattyn F, Hoebeeck J, Robbrecht P, Michels E, De Paepe A, Bottu G, et al.
BMC Bioinformatics
. 2006 Nov;
7:496.
PMID: 17094804
Background: DNA methylation plays an important role in development and tumorigenesis by epigenetic modification and silencing of critical genes. The development of PCR-based methylation assays on bisulphite modified DNA heralded...