Gustavo R Rosania
Overview
Explore the profile of Gustavo R Rosania including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
308
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Recent Articles
1.
Lee A, Shedden K, Rosania G, Crippen G
J Chem Inf Model
. 2008 Jul;
48(7):1379-88.
PMID: 18588283
Elimination of cytotoxic compounds in the early and later stages of drug discovery can help reduce the costs of research and development. Through the application of principal components analysis (PCA),...
2.
Shedden K, Brumer J, Chang Y, Rosania G
J Chem Inf Comput Sci
. 2003 Nov;
43(6):2068-80.
PMID: 14632459
Styryl dyes are fluorescent, lipophilic cations that have been used as specific labeling probes of mitochondria in living cells. For specific applications such as epifluorescence microscopy or flow cytometry, it...
3.
Lee J, Jung M, Rosania G, Chang Y
Chem Commun (Camb)
. 2003 Aug;
(15):1852-3.
PMID: 12931999
A novel cell-permeable DNA fluorescence sensor was developed based on combinatorially-created styryl dyes and cell-based localization screening.
4.
Shedden K, Xie X, Chandaroy P, Chang Y, Rosania G
Cancer Res
. 2003 Aug;
63(15):4331-7.
PMID: 12907600
Anticancer drug resistance results from selective pressure of chemotherapy, together with mutations or epigenetic changes that make cells refractory to treatment. In cancer cells, we report that gene expression associated...
5.
Shedden K, Townsend L, Drach J, Rosania G
Pharm Res
. 2003 Jun;
20(6):843-7.
PMID: 12817886
Purpose: To predict the response of cells to chemotherapeutic agents based on gene expression profiles, we performed a chemoinformatic study of a set of standard anticancer agents assayed for activity...
6.
Rosania G
Curr Top Med Chem
. 2003 Feb;
3(6):659-85.
PMID: 12570858
Supertargeted chemistry is the study of how chemical structures localize or direct molecules to specific sub-cellular compartments in living cells. Supertargeting can be used to increase the activity or specificity...
7.
Rosania G, Lee J, Ding L, Yoon H, Chang Y
J Am Chem Soc
. 2003 Jan;
125(5):1130-1.
PMID: 12553790
The first fluorescent styryl dye library with a broad color range was synthesized by combinatorial condensation of various aldehydes and methyl pyridinium compounds, and their applications as organelle specific staining...
8.
Moon H, Jacobson E, Khersonsky S, Luzung M, Walsh D, Xiong W, et al.
J Am Chem Soc
. 2002 Sep;
124(39):11608-9.
PMID: 12296721
The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.