Gustavo Buchele
Overview
Explore the profile of Gustavo Buchele including associated specialties, affiliations and a list of published articles.
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10
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683
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Recent Articles
1.
Zampieri F, Westphal G, Santos M, Gomes S, Gomes J, Negrelli K, et al.
J Crit Care
. 2024 Aug;
84:154892.
PMID: 39096659
Purpose: To assess the effect of antisense therapy to block kallikrein-kinin pathway in COVID-19 patients. Material And Methods: Randomized, placebo-controlled, double blind, controlled trial enrolling hospitalized COVID-19 patients that required...
2.
Coelho T, Marques Jr W, Dasgupta N, Chao C, Parman Y, Franca Jr M, et al.
JAMA
. 2023 Sep;
330(15):1448-1458.
PMID: 37768671
Importance: Transthyretin gene silencing is an emerging treatment strategy for hereditary transthyretin (ATTRv) amyloidosis. Objective: To evaluate eplontersen, an investigational ligand-conjugated antisense oligonucleotide, in ATTRv polyneuropathy. Design, Setting, And Participants:...
3.
Brannagan 3rd T, Berk J, Gillmore J, Maurer M, Waddington-Cruz M, Fontana M, et al.
J Peripher Nerv Syst
. 2022 Nov;
27(4):228-237.
PMID: 36345805
Transthyretin-mediated amyloidosis (ATTR) is a rare, under-recognized, progressively debilitating, fatal disease caused by the aggregation and extracellular deposition of amyloid transthyretin (TTR) fibrils in multiple organs and tissues throughout the...
4.
Coles T, Hernandez A, Reeve B, Cook K, Edwards M, Boutin M, et al.
Health Qual Life Outcomes
. 2021 Jun;
19(1):164.
PMID: 34120618
Objectives: There has been limited success in achieving integration of patient-reported outcomes (PROs) in clinical trials. We describe how stakeholders envision a solution to this challenge. Methods: Stakeholders from academia,...
5.
Coelho T, Ando Y, Benson M, Berk J, Waddington-Cruz M, Dyck P, et al.
Neurol Ther
. 2021 Feb;
10(1):375-389.
PMID: 33638113
Introduction: AKCEA-TTR-L is a ligand-conjugated antisense (LICA) drug in development for the treatment of hereditary transthyretin amyloidosis (hATTR), a fatal disease caused by mutations in the transthyretin (TTR) gene. AKCEA-TTR-L...
6.
Viney N, Guo S, Tai L, Baker B, Aghajan M, Jung S, et al.
ESC Heart Fail
. 2020 Dec;
8(1):652-661.
PMID: 33283485
Aims: Amyloidogenic transthyretin (ATTR) amyloidosis is a fatal disease characterized by progressive cardiomyopathy and/or polyneuropathy. AKCEA-TTR-L (ION-682884) is a ligand-conjugated antisense drug designed for receptor-mediated uptake by hepatocytes, the primary...
7.
Teerlink J, Diaz R, Felker G, McMurray J, Metra M, Solomon S, et al.
JACC Heart Fail
. 2020 Feb;
8(4):329-340.
PMID: 32035892
A central factor in the pathogenesis of heart failure (HF) with reduced ejection fraction is the initial decrease in systolic function. Prior attempts at increasing cardiac contractility with oral drugs...
8.
Ospina-Tascon G, Neves A, Occhipinti G, Donadello K, Buchele G, Simion D, et al.
Intensive Care Med
. 2010 Mar;
36(6):949-55.
PMID: 20221744
Purpose: To evaluate the effects of fluid administration on microcirculatory alterations in sepsis. Methods: With a Sidestream Dark Field device, we evaluated the effects of fluids on the sublingual microcirculation...
9.
De Backer D, Hollenberg S, Boerma C, Goedhart P, Buchele G, Ospina-Tascon G, et al.
Crit Care
. 2007 Sep;
11(5):R101.
PMID: 17845716
Introduction: Microvascular alterations may play an important role in the development of organ failure in critically ill patients and especially in sepsis. Recent advances in technology have allowed visualization of...
10.
Creteur J, Carollo T, Soldati G, Buchele G, De Backer D, Vincent J
Intensive Care Med
. 2007 Jun;
33(9):1549-56.
PMID: 17572876
Objective: To quantify sepsis-induced alterations in changes in muscle tissue oxygenation (StO(2)) after an ischemic challenge using near-infrared spectroscopy (NIRS), and to test the hypothesis that these alterations are related...