Guillaume Lenormand
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Explore the profile of Guillaume Lenormand including associated specialties, affiliations and a list of published articles.
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14
Citations
579
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Recent Articles
1.
Mizrahi N, Zhou E, Lenormand G, Krishnan R, Weihs D, Butler J, et al.
Soft Matter
. 2013 May;
8(8):2438-2443.
PMID: 23646063
Therapeutic ultrasound is widely employed in clinical applications but its mechanism of action remains unclear. Here we report prompt fluidization of a cell and dramatic acceleration of its remodeling dynamics...
2.
Coughlin M, Bielenberg D, Lenormand G, Marinkovic M, Waghorne C, Zetter B, et al.
Clin Exp Metastasis
. 2012 Sep;
30(3):237-50.
PMID: 22961212
We quantified mechanical properties of cancer cells differing in metastatic potential. These cells included normal and H-ras-transformed NIH3T3 fibroblast cells, normal and oncoprotein-overexpressing MCF10A breast cancer cells, and weakly and...
3.
Lenormand G, Millet E, Park C, Hardin C, Butler J, Moldovan N, et al.
Phys Rev E Stat Nonlin Soft Matter Phys
. 2011 Jul;
83(6 Pt 1):061918.
PMID: 21797414
The principal constituent of the living cell is water. The role of the hydration shell and bulk H(2)O solvent is well recognized in the dynamics of isolated proteins, but the...
4.
Oliver M, Kovats T, Mijailovich S, Butler J, Fredberg J, Lenormand G
Phys Rev Lett
. 2011 Jan;
105(15):158102.
PMID: 21230941
Here we investigate the origin of relaxation times governing the mechanical response of an integrated contractile tissue to imposed cyclic changes of length. When strain-rate amplitude is held constant as...
5.
Lin Y, Tambe D, Park C, Wasserman M, Trepat X, Krishnan R, et al.
Phys Rev E Stat Nonlin Soft Matter Phys
. 2011 Jan;
82(4 Pt 1):041918.
PMID: 21230324
Structure and function of the adherent cell depend in a crucial way on its microenvironment, including the stiffness of its substrate. It is often asserted that substrate thickness (as opposed...
6.
DiPaolo B, Lenormand G, Fredberg J, Margulies S
Am J Physiol Cell Physiol
. 2010 Jun;
299(2):C345-53.
PMID: 20519449
Alveolar epithelial cells (AEC) maintain integrity of the blood-gas barrier with gasket-like intercellular tight junctions (TJ) that are anchored internally to the actin cytoskeleton. We hypothesize that stretch rapidly reorganizes...
7.
Krishnan R, Park C, Lin Y, Mead J, Jaspers R, Trepat X, et al.
PLoS One
. 2009 May;
4(5):e5486.
PMID: 19424501
Every adherent eukaryotic cell exerts appreciable traction forces upon its substrate. Moreover, every resident cell within the heart, great vessels, bladder, gut or lung routinely experiences large periodic stretches. As...
8.
Mott A, Lenormand G, Costales J, Fredberg J, Burleigh B
J Cell Physiol
. 2008 Oct;
218(2):315-22.
PMID: 18853412
To investigate the effects of Trypanosoma cruzi on the mechanical properties of infected host cells, cytoskeletal stiffness and remodeling dynamics were measured in parasite-infected fibroblasts. We find that cell stiffness...
9.
Krishnan R, Trepat X, Nguyen T, Lenormand G, Oliver M, Fredberg J
Respir Physiol Neurobiol
. 2008 Jun;
163(1-3):17-24.
PMID: 18514592
We review here four recent findings that have altered in a fundamental way our understanding of airways smooth muscle (ASM), its dynamic responses to physiological loading, and their dominant mechanical...
10.
Lenormand G, Bursac P, Butler J, Fredberg J
Phys Rev E Stat Nonlin Soft Matter Phys
. 2007 Nov;
76(4 Pt 1):041901.
PMID: 17995020
We report here measurements of rheological properties of the human airway smooth muscle cell using forced nanoscale motions of Arg-Gly-Asp RGD-coated microbeads tightly bound to the cytoskeleton. With changes of...