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Gudrun Rutsdottir

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Articles 15
Citations 138
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Recent Articles
1.
Kjaersgaard Andersen R, Stefansdottir L, Riis P, Halldorsson G, Ferkingstad E, Oddsson A, et al.
J Am Acad Dermatol . 2024 Dec; PMID: 39645042
Background: The contributions of genetic and environmental risk factors to hidradenitis suppurativa (HS) are both poorly understood. Objective: To identify sequence variants that associate with HS and determine the contribution...
2.
Kristjansdottir K, Norddahl G, Ivarsdottir E, Halldorsson G, Einarsson G, Bjarnadottir K, et al.
J Allergy Clin Immunol . 2024 Oct; 155(1):228-235. PMID: 39423878
Background: Signal transducer and activator of transcription 6 (STAT6) is central to type 2 (T2) inflammation, and common noncoding variants at the STAT6 locus associate with various T2 inflammatory traits,...
3.
Saevarsdottir S, Bjarnadottir K, Markusson T, Berglund J, Olafsdottir T, Halldorsson G, et al.
Nat Commun . 2024 Jul; 15(1):5748. PMID: 38982041
Autoimmune thyroid disease (AITD) is a common autoimmune disease. In a GWAS meta-analysis of 110,945 cases and 1,084,290 controls, 290 sequence variants at 225 loci are associated with AITD. Of...
4.
Gisladottir R, Helgason A, Halldorsson B, Helgason H, Borsky M, Chien Y, et al.
Sci Adv . 2023 Jun; 9(23):eabq2969. PMID: 37294764
The genetic basis of the human vocal system is largely unknown, as are the sequence variants that give rise to individual differences in voice and speech. Here, we couple data...
5.
Aegisdottir H, Thorolfsdottir R, Sveinbjornsson G, Stefansson O, Gunnarsson B, Tragante V, et al.
Eur Heart J . 2023 Feb; 44(12):1070-1080. PMID: 36747475
Aims: Syncope is a common and clinically challenging condition. In this study, the genetics of syncope were investigated to seek knowledge about its pathophysiology and prognostic implications. Methods And Results:...
6.
Saevarsdottir S, Stefansdottir L, Sulem P, Thorleifsson G, Ferkingstad E, Rutsdottir G, et al.
Ann Rheum Dis . 2022 Apr; 81(8):1085-1095. PMID: 35470158
Objectives: To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. Methods: We performed a genome-wide association study (GWAS) of 31 313...
7.
Gisladottir R, Ivarsdottir E, Helgason A, Jonsson L, Hannesdottir N, Rutsdottir G, et al.
Curr Biol . 2020 Oct; 30(23):4643-4653.e3. PMID: 33035477
Olfactory receptor (OR) genes in humans form a special class characterized by unusually high DNA sequence diversity, which should give rise to differences in perception and behavior. In the largest...
8.
Soderberg C, Mansson C, Bernfur K, Rutsdottir G, Harmark J, Rajan S, et al.
Sci Rep . 2018 Mar; 8(1):5199. PMID: 29581438
The remarkably efficient suppression of amyloid fibril formation by the DNAJB6 chaperone is dependent on a set of conserved S/T-residues and an oligomeric structure, features unusual among DNAJ chaperones. We...
9.
Rutsdottir G, Rasmussen M, Hojrup P, Bernfur K, Emanuelsson C, Soderberg C
Proteins . 2017 Oct; 86(1):110-123. PMID: 29082555
The small heat shock protein (sHsp) chaperones are important for stress survival, yet the molecular details of how they interact with client proteins are not understood. All sHsps share a...
10.
Bernfur K, Rutsdottir G, Emanuelsson C
Protein Sci . 2017 Jun; 26(9):1773-1784. PMID: 28608391
The small heat shock protein (sHsp) chaperones are crucial for cell survival and can prevent aggregation of client proteins that partially unfold under destabilizing conditions. Most investigations on the chaperone...