GuanQun Liu
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Explore the profile of GuanQun Liu including associated specialties, affiliations and a list of published articles.
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53
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1144
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Recent Articles
1.
Sarkar L, Liu G, Acharya D, Zhu J, Sayyad Z, Gack M
bioRxiv
. 2024 Oct;
PMID: 39386617
The posttranslational modification (PTM) of innate immune sensor proteins by ubiquitin or ubiquitin-like proteins is crucial for regulating antiviral host responses. The cytoplasmic dsRNA receptor melanoma differentiation-associated protein 5 (MDA5)...
2.
Zhu J, Liu G, Sayyad Z, Goins C, Stauffer S, Gack M
J Virol
. 2024 Aug;
98(9):e0086924.
PMID: 39194248
Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like protein, is covalently conjugated to host immune proteins such as MDA5 and IRF3 in a process called ISGylation, thereby promoting type I IFN...
3.
Zhu J, Liu G, Goins C, Stauffer S, Gack M
bioRxiv
. 2024 Aug;
PMID: 39149229
Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like protein, is covalently conjugated to host (immune) proteins such as MDA5 and IRF3 in a process called ISGylation, thereby limiting the replication of...
4.
Chauvin S, Ando S, Holley J, Sugie A, Zhao F, Poddar S, et al.
Nat Commun
. 2024 Jun;
15(1):4696.
PMID: 38824133
Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to the brain, retina, liver, and kidney. Based on the DNA damage theory of aging, we reasoned that genomic...
5.
Bazzone L, Zhu J, King M, Liu G, Guo Z, MacKay C, et al.
Nat Commun
. 2024 May;
15(1):4153.
PMID: 38755212
Viral myocarditis, an inflammatory disease of the heart, causes significant morbidity and mortality. Type I interferon (IFN)-mediated antiviral responses protect against myocarditis, but the mechanisms are poorly understood. We previously...
6.
Cheng D, Zhu J, Liu G, Gack M, MacDuff D
bioRxiv
. 2024 Apr;
PMID: 38617308
The RIG-I-like receptors (RLRs), RIG-I and MDA5, are innate sensors of RNA virus infections that are critical for mounting a robust antiviral immune response. We have shown previously that HOIL1,...
7.
Li Z, Zheng X, Mu Y, Zhang M, Liu G
Phys Med Biol
. 2023 Aug;
68(18).
PMID: 37619578
. Intestinal metaplasia (IM) is a common precancerous condition for gastric cancer, and the risk of developing gastric cancer increases as IM worsens. However, current deep learning-based methods cannot effectively...
8.
Sarkar L, Liu G, Gack M
Trends Microbiol
. 2023 Aug;
31(12):1262-1275.
PMID: 37573184
Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like pleiotropic protein and one of the most abundant ISGs, has been studied extensively; however, its roles in SARS-CoV-2 and other viral infections have...
9.
Afsar M, Liu G, Jia L, Ruben E, Nayak D, Sayyad Z, et al.
Nat Commun
. 2023 Aug;
14(1):4786.
PMID: 37553340
ISG15 plays a crucial role in the innate immune response and has been well-studied due to its antiviral activity and regulation of signal transduction, apoptosis, and autophagy. ISG15 is a...
10.
Serman T, Chiang C, Liu G, Sayyad Z, Pandey S, Volcic M, et al.
Cell Host Microbe
. 2023 Jul;
31(8):1317-1330.e10.
PMID: 37478852
Direct targeting of essential viral enzymes such as proteases, polymerases, and helicases has long been the major focus of antiviral drug design. Although successful for some viral enzymes, targeting viral...