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Guangsheng Du

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Articles 59
Citations 666
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Recent Articles
1.
Tang X, Deng J, He C, Xu Y, Bai S, Guo Z, et al.
J Control Release . 2025 Mar; :113629. PMID: 40086761
Subunit vaccines are crucial in preventing modern diseases due to their safety, stability, and ability to elicit targeted immune responses. However, challenges in antigen and adjuvant design hinder their development....
2.
He C, He P, Ou Y, Tang X, Wei H, Xu Y, et al.
ACS Nano . 2025 Jan; 19(5):5549-5567. PMID: 39879106
Contemporary osteoporosis treatment often neglects the intricate interactions among immune cells, signaling proteins, and cytokines within the osteoporotic microenvironment. Here, we developed core-shell nanocapsules composed of a cationized lactoferrin core...
3.
He P, He C, Wu F, Ou Y, Luo S, Zhang Y, et al.
J Control Release . 2025 Jan; 379:1045-1057. PMID: 39875077
Adeno-associated viruses (AAV) have significant potential as vaccine carriers due to their excellent biosafety and efficient antigen gene delivery. However, most AAV vaccines show limited capacity to transduce antigen-presenting cells...
4.
Guo Z, Wu F, Guo C, Hu R, Ou Y, Zhu Y, et al.
Adv Mater . 2025 Jan; 37(8):e2412627. PMID: 39828538
Recombinant adeno-associated viruses (rAAVs) have emerged as promising vaccine vectors due to their enduring efficacy with a single dose. However, insufficient cellular immune responses and the random and non-specific distribution...
5.
Guo Z, Guo C, Song Y, He C, He P, Wu F, et al.
J Control Release . 2025 Jan; 379:177-190. PMID: 39788375
Most subunit antigens often induce suboptimal vaccination efficacy, possibly due to their low immunogenicity and limited ability to migrate to lymph nodes (LNs). Although the emergence of nanovaccine has significantly...
6.
Jiang Z, Xu Y, Du G, Sun X
J Control Release . 2024 Apr; 370:287-301. PMID: 38679162
The success of lipid nanoparticles (LNPs) in treating COVID-19 promotes further research of mRNA vaccines for cancer vaccination. Aiming at overcoming the constraints of currently available mRNA carriers, various alternative...
7.
Liu L, Wang R, Sun Y, Xiao Y, Du G, Zhang Q
Front Psychol . 2024 Mar; 15:1281469. PMID: 38445051
Objective: Our aim is to investigate the cut-off point of distress and the influencing factors associated with distress in patients with newly diagnosed breast cancer. Methods: A cross-sectional survey of...
8.
Guo J, Su L, Du G, Chen Y, Liu C, Wang B, et al.
Gut . 2024 Feb; 73(12):1964-1983. PMID: 38418212
No abstract available.
9.
Zhang Y, Yang L, Ou Y, Hu R, Du G, Luo S, et al.
Acta Pharm Sin B . 2024 Jan; 14(1):350-364. PMID: 38261817
Recent clinical studies have shown that mutation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene in cancer cells may be associated with immunosuppressive tumor microenvironment (TME) and...
10.
Zhao J, He P, Jiang M, He C, Zhao Y, Zhang Z, et al.
J Control Release . 2024 Jan; 366:637-649. PMID: 38215983
Induction of antigen-specific immune tolerance for the treatment of allergic or autoimmune diseases is an attractive strategy. Herein, we investigated the protective effect of a transdermal microneedle patch against allergic...