Guanghong Wei
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Explore the profile of Guanghong Wei including associated specialties, affiliations and a list of published articles.
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149
Citations
2074
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Recent Articles
1.
Zhang X, Chen Y, Tan Y, Pan T, Wei G
Curr Protein Pept Sci
. 2025 Feb;
PMID: 39950286
The misfolding and aggregation of amyloid proteins are closely associated with a range of neurodegenerative diseases. Liquid-liquid phase separation (LLPS) can initiate the aggregation of proteins, indicating that LLPS may...
2.
Fan X, Tang Y, Zhang J, Ma K, Xu Z, Liu Y, et al.
Adv Sci (Weinh)
. 2025 Jan;
e2410471.
PMID: 39840461
Bioinspired supramolecular architectonics is attracting increasing interest due to their flexible organization and multifunctionality. However, state-of-the-art bioinspired architectonics generally take place in solvent-based circumstance, thus leading to achieving precise control...
3.
Ning S, Qin Y, Xie Y, Liang Y, Liang Y, Wei G, et al.
Hemoglobin
. 2024 Dec;
48(6):384-388.
PMID: 39694851
In southern China, α-thalassemia is the most prevalent hereditary monogenic disorder, and deletion variants are the predominant form. Conventional thalassemia diagnosis techniques are numerous, however they are all limited in...
4.
Zeng J, Yang Z, Tang Y, Wei G
ACS Chem Neurosci
. 2024 Nov;
15(23):4241-4244.
PMID: 39555603
Intrinsically disordered proteins (IDPs) are closely associated with a number of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Due to the highly dynamic nature of IDPs, their structural...
5.
Chen Y, Sun X, Tang Y, Tan Y, Guo C, Pan T, et al.
Small
. 2024 Oct;
21(6):e2406429.
PMID: 39421885
Liquid-liquid phase separation (LLPS) of tau protein can initiate its aggregation which is associated with Alzheimer's disease. The pathogenic mutation ΔK280 can enhance the aggregation of K18, a truncated tau...
6.
Yu Y, Liu Q, Zeng J, Tan Y, Tang Y, Wei G
Chem Sci
. 2024 Aug;
15(32):12806-12818.
PMID: 39148776
Liquid-Liquid phase separation (LLPS) of p53 to form liquid condensates has been implicated in cellular functions and dysfunctions. The p53 condensates may serve as amyloid fibril precursors to initiate p53...
7.
Liu Q, Yu Y, Wei G
Phys Chem Chem Phys
. 2024 Jul;
26(29):20068-20086.
PMID: 39007865
The involvement of p53 aggregation in cancer pathogenesis emphasizes the importance of unraveling the mechanisms underlying mutation-induced p53 destabilization. And understanding how small molecule inhibitors prevent the conversion of p53...
8.
Lao Z, Tang Y, Dong X, Tan Y, Li X, Liu X, et al.
Nanoscale
. 2024 Feb;
16(8):4025-4038.
PMID: 38347806
Many RNA-binding proteins such as fused-in sarcoma (FUS) can self-assemble into reversible liquid droplets and fibrils through the self-association of their low-complexity (LC) domains. Recent experiments have revealed that SYG-rich...
9.
Qiao Q, Wei G, Song Z
Phys Chem Chem Phys
. 2024 Feb;
26(8):7090-7102.
PMID: 38345763
Amyloid deposits of the human islet amyloid polypeptide (hIAPP) have been identified in 90% of patients with type II diabetes. Cellular membranes accelerate the hIAPP fibrillation, and the integrity of...
10.
Chen Y, Zhan C, Li X, Pan T, Yao Y, Tan Y, et al.
Int J Biol Macromol
. 2023 Nov;
256(Pt 2):128467.
PMID: 38035959
Alzheimer's disease (AD) is associated with the deposition of amyloid-β (Aβ) fibrillary aggregates. Disaggregation of Aβ fibrils is considered as one of the promising AD treatments. Recent experimental studies showed...