Guangfeng Ruan
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Explore the profile of Guangfeng Ruan including associated specialties, affiliations and a list of published articles.
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Articles
49
Citations
258
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Recent Articles
1.
Wen S, Xu S, Zong X, Wen S, Xiao W, Zheng W, et al.
J Cachexia Sarcopenia Muscle
. 2025 Feb;
16(1):e13720.
PMID: 39949133
Background: Sarcopenia severely affects the physical health of the elderly. Currently, there is no specific drug available for sarcopenia. This study aims to identify pathogenic proteins and druggable targets for...
2.
Liu P, Zhou J, Cui H, Xu J, Ruan G, Ding C, et al.
Clin Rheumatol
. 2025 Jan;
44(2):811-822.
PMID: 39775461
Objective: Nuclear transcription factor-κB (NF-κB) activation is a pivotal event in the pathogenesis of osteoarthritis (OA). OA patients frequently exhibit vitamin D (VD) deficiency, which is commonly associated with NF-κB...
3.
Xu S, Wen S, Zong X, Wen S, Zhu J, Zheng W, et al.
Hypertension
. 2024 Dec;
82(2):333-346.
PMID: 39624895
Background: Circulating proteins in blood are involved in various physiological processes, but their contributions to blood pressure regulation remain partially understood. In traditional observational studies, identifying circulating proteins causally associated...
4.
Liu Z, Chen Z, Wu Z, Tang M, Lin Y, Wu C, et al.
BMC Musculoskelet Disord
. 2024 Nov;
25(1):973.
PMID: 39604894
Background: To investigate the associations between folate intake and changes in knee pain, inflammation mediators and comorbid conditions over 2 years in patients with symptomatic knee osteoarthritis (OA). Methods: A...
5.
Li D, Cai D, Xie D, Wang L, Zhang Y, Ruan G, et al.
Bone
. 2024 Oct;
190:117285.
PMID: 39426581
Bone healing requires well-orchestrated sequential actions of osteoblasts and osteoclasts. Previous studies have demonstrated that the mechanistic target of rapamycin complex 1 (mTORC1) plays a critical role in the metabolism...
6.
Xing X, Xu S, Wang Y, Shen Z, Wen S, Zhang Y, et al.
Diabetes
. 2024 Oct;
74(1):108-119.
PMID: 39418314
Article Highlights:
7.
Liang W, Feng R, Li X, Duan X, Feng S, Chen J, et al.
Nat Commun
. 2024 Oct;
15(1):8792.
PMID: 39389988
Abnormal subchondral bone remodeling plays a pivotal role in the progression of osteoarthritis (OA). Here, we analyzed subchondral bone samples from OA patients and observed a significant upregulation of ubiquitin...
8.
Wu C, Huang Z, Chen J, Li N, Cai Y, Chen J, et al.
Biomaterials
. 2024 Jul;
312:122720.
PMID: 39084098
Mesenchymal stem cells (MSCs) are expected to be useful therapeutics in osteoarthritis (OA), the most common joint disorder characterized by cartilage degradation. However, evidence is limited with regard to cartilage...
9.
Li S, Cao P, Li J, Chen T, Luo P, Ruan G, et al.
Arthritis Rheumatol
. 2024 May;
76(9):1377-1386.
PMID: 38751101
Objective: Accurately predicting knee osteoarthritis (KOA) is essential for early detection and personalized treatment. We aimed to develop and test a magnetic resonance imaging (MRI)-based joint space (JS) radiomic model...
10.
Ou Q, Tang S, Zhu J, Xue S, Huang H, Zhao Y, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Feb;
1870(4):167083.
PMID: 38367900
Objective: Spermidine (SPD) is an anti-aging natural substance, and it exerts effects through anti-apoptosis and anti-inflammation. However, the specific protective mechanism of SPD in osteoarthritis (OA) remains unclear. Here, we...