Guangchun Fan
Overview
Explore the profile of Guangchun Fan including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
17
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Recent Articles
1.
Dong H, Zhang X, Duan Y, He Y, Zhao J, Wang Z, et al.
J Neuroinflammation
. 2024 Mar;
21(1):80.
PMID: 38555419
Neuroinflammation is one of the core pathological features of Parkinson's disease (PD). Innate immune cells play a crucial role in the progression of PD. Microglia, the major innate immune cells...
2.
Zhang X, Zhang Y, Wang B, Xie C, Wang J, Fang R, et al.
Brain Behav Immun
. 2024 Mar;
119:129-145.
PMID: 38552923
GSDMD-mediated pyroptosis occurs in the nigrostriatal pathway in Parkinson's disease animals, yet the role of GSDMD in neuroinflammation and death of dopaminergic neurons in Parkinson's disease remains elusive. Here, our...
3.
Fan G, Chen S, Liang L, Zhang H, Yu R
Int J Mol Sci
. 2022 Dec;
23(24).
PMID: 36555637
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) exerts effective neuroprotective activity through its specific receptor, PAC1-R. We accidentally discovered that as a positive allosteric modulator (PAM) of PAC1-R, the small-molecule...
4.
Fan G, Chen S, Tao Z, Zhang H, Yu R
Acta Biochim Biophys Sin (Shanghai)
. 2022 Sep;
54(9):1349-1364.
PMID: 36082935
As a neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP)-preferring receptor, PAC1-R mediates effective neuroprotective activity. Based on the finding that the antibiotic doxycycline (DOX) with clinical neuroprotective activity functions as a...
5.
Fan G, Tao Z, Chen S, Zhang H, Yu R
Acta Biochim Biophys Sin (Shanghai)
. 2022 May;
54(5):657-672.
PMID: 35593471
PAC1-R is a recognized preferential receptor for the neuropeptide of pituitary adenylate cyclase-activating polypeptide (PACAP), which mediates neuroprotective and nerve regenerative activities of PACAP. In this study, we found that...
6.
Yu R, Lin Z, Ouyang Z, Tao Z, Fan G
Biochim Biophys Acta Gen Subj
. 2021 Mar;
1865(6):129884.
PMID: 33647387
PAC1-R is neuropeptide PACAP (pituitary adenylate cyclase activating polypeptide) preferring receptor mediates the antioxidant and cytoprotective effects of PACAP. It was found in this research that in both PAC1R-CHO cells...