Gregory O Staples
Overview
Explore the profile of Gregory O Staples including associated specialties, affiliations and a list of published articles.
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19
Citations
447
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Recent Articles
1.
Mouchahoir T, Schiel J, Rogers R, Heckert A, Place B, Ammerman A, et al.
J Am Soc Mass Spectrom
. 2022 Aug;
33(9):1659-1677.
PMID: 36018776
The multi-attribute method (MAM) was conceived as a single assay to potentially replace multiple single-attribute assays that have long been used in process development and quality control (QC) for protein...
2.
Mouchahoir T, Schiel J, Rogers R, Heckert A, Place B, Ammerman A, et al.
J Am Soc Mass Spectrom
. 2021 Mar;
32(4):913-928.
PMID: 33710905
The Multi-Attribute Method (MAM) Consortium was initially formed as a venue to harmonize best practices, share experiences, and generate innovative methodologies to facilitate widespread integration of the MAM platform, which...
3.
Stoll D, Lhotka H, Harmes D, Madigan B, Hsiao J, Staples G
J Chromatogr B Analyt Technol Biomed Life Sci
. 2019 Dec;
1134-1135:121832.
PMID: 31790917
Separations of complex peptide mixtures have been a common target application for two-dimensional liquid chromatography over the last few decades. These separations have most frequently been carried out at the...
4.
De Leoz M, Duewer D, Fung A, Liu L, Yau H, Potter O, et al.
Mol Cell Proteomics
. 2019 Oct;
19(1):11-30.
PMID: 31591262
Glycosylation is a topic of intense current interest in the development of biopharmaceuticals because it is related to drug safety and efficacy. This work describes results of an interlaboratory study...
5.
Stoll D, Harmes D, Staples G, Potter O, Dammann C, Guillarme D, et al.
Anal Chem
. 2018 Apr;
90(9):5923-5929.
PMID: 29614857
Monoclonal antibodies (mAb) and related molecules are being developed at a remarkable pace as new therapeutics for the treatment of diseases ranging from cancer to inflammatory disorders. However, characterization of...
6.
Sorensen M, Harmes D, Stoll D, Staples G, Fekete S, Guillarme D, et al.
MAbs
. 2016 Jul;
8(7):1224-1234.
PMID: 27362833
As research, development, and manufacturing of biosimilar protein therapeutics proliferates, there is great interest in the continued development of a portfolio of complementary analytical methods that can be used to...
7.
Staples G, Zaia J
Curr Proteomics
. 2015 Feb;
8(4):325-336.
PMID: 25705143
The glycosaminoglycans (GAGs) are linear polysaccharides expressed on animal cell surfaces and in extracellular matrices. Their biosynthesis is under complex control and confers a domain structure that is essential to...
8.
Khatri K, Staples G, Leymarie N, Leon D, Turiak L, Huang Y, et al.
J Proteome Res
. 2014 Aug;
13(10):4347-55.
PMID: 25153361
A glycoprotein may contain several sites of glycosylation, each of which is heterogeneous. As a consequence of glycoform diversity and signal suppression from nonglycosylated peptides that ionize more efficiently, typical...
9.
Mathias D, Pastrana-Mena R, Ranucci E, Tao D, Ferruti P, Ortega C, et al.
PLoS Pathog
. 2013 Nov;
9(11):e1003757.
PMID: 24278017
Malaria transmission-blocking (T-B) interventions are essential for malaria elimination. Small molecules that inhibit the Plasmodium ookinete-to-oocyst transition in the midgut of Anopheles mosquitoes, thereby blocking sporogony, represent one approach to...
10.
Leymarie N, Griffin P, Jonscher K, Kolarich D, Orlando R, McComb M, et al.
Mol Cell Proteomics
. 2013 Jun;
12(10):2935-51.
PMID: 23764502
One of the principal goals of glycoprotein research is to correlate glycan structure and function. Such correlation is necessary in order for one to understand the mechanisms whereby glycoprotein structure...