Gregg E Homanics
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Explore the profile of Gregg E Homanics including associated specialties, affiliations and a list of published articles.
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143
Citations
3805
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Recent Articles
1.
Kambali M, Li Y, Unichenko P, Feria Pliego J, Yadav R, Liu J, et al.
Mol Psychiatry
. 2024 Aug;
30(3):927-942.
PMID: 39210012
Glycine is an obligatory co-agonist at excitatory NMDA receptors in the brain, especially in the dentate gyrus, which has been postulated to be crucial for the development of psychotic associations...
2.
Myers T, Li Y, Taiclet S, Cabada-Aguirre P, Kuti E, McClure K, et al.
Sci Rep
. 2024 Aug;
14(1):18575.
PMID: 39127839
Triosephosphate isomerase deficiency (TPI Df) is a rare multisystem disorder with severe neuromuscular symptoms which arises exclusively from mutations within the TPI1 gene. Studies of TPI Df have been limited...
3.
Homanics G
Alcohol
. 2024 Jul;
120:99-107.
PMID: 38971210
The white-tufted marmoset is a small, nonhuman primate that is rapidly gaining popularity as a model organism, especially for neuroscience research. To date, little work in the alcohol research field...
4.
Hoisington Z, Gangal H, Phamluong K, Shukla C, Ehinger Y, Moffat J, et al.
bioRxiv
. 2024 Jun;
PMID: 38915579
Prosapip1 is a brain-specific protein localized to the postsynaptic density, where it promotes dendritic spine maturation in primary hippocampal neurons. However, nothing is known about the role of Prosapip1 in...
5.
Blednov Y, Shawlot W, Homanics G, Osterndorff-Kahanek E, Mason S, Mayfield J, et al.
Neuropharmacology
. 2024 Jun;
257:110035.
PMID: 38876310
We previously showed that the PDE4 inhibitor apremilast reduces ethanol consumption in mice by protein kinase A (PKA) and GABAergic mechanisms. Preventing PKA phosphorylation of GABA β3 subunits partially blocked...
6.
San Martin L, Armijo-Weingart L, Gallegos S, Araya A, Homanics G, Aguayo L
Life Sci
. 2024 Apr;
348:122673.
PMID: 38679193
Aims: Glycine receptors (GlyRs) are potentiated by physiologically relevant concentrations of ethanol, and mutations in the intracellular loop of α1 and α2 subunits reduced the effect of the drug. Knock-in...
7.
Homanics G, Park J, Bailey L, Schaeffer D, Schaeffer L, He J, et al.
Alzheimers Dement
. 2024 Apr;
20(5):3455-3471.
PMID: 38574388
Introduction: Fundamental questions remain about the key mechanisms that initiate Alzheimer's disease (AD) and the factors that promote its progression. Here we report the successful generation of the first genetically...
8.
Dilly G, Blednov Y, Warden A, Ezerskiy L, Fleischer C, Plotkin J, et al.
Brain Behav Immun
. 2024 Mar;
118:437-448.
PMID: 38499210
Systemic activation of toll-like receptor 3 (TLR3) signaling using poly(I:C), a TLR3 agonist, drives ethanol consumption in several rodent models, while global knockout of Tlr3 reduces drinking in C57BL/6J male...
9.
Rice R, Gil D, Baratta A, Frawley R, Hill S, Farris S, et al.
Neurobiol Stress
. 2024 Jan;
29:100603.
PMID: 38234394
Chronic stress and alcohol (ethanol) use are highly interrelated and can change an individual's behavior through molecular adaptations that do not change the DNA sequence, but instead change gene expression....
10.
Okhuarobo A, Kreifeldt M, Gandhi P, Lopez C, Martinez B, Fleck K, et al.
Mol Psychiatry
. 2023 Dec;
29(2):529-542.
PMID: 38135755
Large conductance potassium (BK) channels are among the most sensitive molecular targets of ethanol and genetic variations in the channel-forming α subunit have been nominally associated with alcohol use disorders....