Greg McMullan
Overview
Explore the profile of Greg McMullan including associated specialties, affiliations and a list of published articles.
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9
Citations
1620
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Recent Articles
1.
McMullan G, Naydenova K, Mihaylov D, Yamashita K, Peet M, Wilson H, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(49):e2312905120.
PMID: 38011573
Electron cryomicroscopy can, in principle, determine the structures of most biological molecules but is currently limited by access, specimen preparation difficulties, and cost. We describe a purpose-built instrument operating at...
2.
Glaeser R, Hagen W, Han B, Henderson R, McMullan G, Russo C
Ultramicroscopy
. 2021 Feb;
222:113213.
PMID: 33524638
The brightness of modern Schottky field-emission guns can produce electron beams that have very high spatial coherence, especially for the weak-illumination conditions that are used for single-particle electron cryo-microscopy in...
3.
Nakane T, Kotecha A, Sente A, McMullan G, Masiulis S, Brown P, et al.
Nature
. 2020 Oct;
587(7832):152-156.
PMID: 33087931
The three-dimensional positions of atoms in protein molecules define their structure and their roles in biological processes. The more precisely atomic coordinates are determined, the more chemical information can be...
4.
Bai X, McMullan G, Scheres S
Trends Biochem Sci
. 2014 Dec;
40(1):49-57.
PMID: 25544475
For many years, structure determination of biological macromolecules by cryo-electron microscopy (cryo-EM) was limited to large complexes or low-resolution models. With recent advances in electron detection and image processing, the...
5.
Vinothkumar K, McMullan G, Henderson R
Structure
. 2014 Mar;
22(4):621-7.
PMID: 24613486
Binding of a single-chain Fv antibody to Escherichia coli β-galactosidase (β-gal) is known to stabilize the enzyme and activate several inactive point mutants, historically called antibody-mediated enzyme formation mutants. To...
6.
Allegretti M, Mills D, McMullan G, Kuhlbrandt W, Vonck J
Elife
. 2014 Feb;
3:e01963.
PMID: 24569482
The introduction of direct electron detectors with higher detective quantum efficiency and fast read-out marks the beginning of a new era in electron cryo-microscopy. Using the FEI Falcon II direct...
7.
Chen S, McMullan G, Faruqi A, Murshudov G, Short J, Scheres S, et al.
Ultramicroscopy
. 2013 Jul;
135:24-35.
PMID: 23872039
Three-dimensional (3D) structure determination by single particle electron cryomicroscopy (cryoEM) involves the calculation of an initial 3D model, followed by extensive iterative improvement of the orientation determination of the individual...
8.
Bai X, Fernandez I, McMullan G, Scheres S
Elife
. 2013 Feb;
2:e00461.
PMID: 23427024
Although electron cryo-microscopy (cryo-EM) single-particle analysis has become an important tool for structural biology of large and flexible macro-molecular assemblies, the technique has not yet reached its full potential. Besides...
9.
Henderson R, McMullan G
Microscopy (Oxf)
. 2013 Jan;
62(1):43-50.
PMID: 23291269
Theoretical considerations together with simulations of single-particle electron cryomicroscopy images of biological assemblies in ice demonstrate that atomic structures should be obtainable from images of a few thousand asymmetric units,...