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Grant Hoyt

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Articles 28
Citations 1109
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Recent Articles
1.
Swijnenburg R, Govaert J, Van der Bogt K, Pearl J, Huang M, Stein W, et al.
Circ Cardiovasc Imaging . 2009 Nov; 3(1):77-85. PMID: 19920031
Background: Despite ongoing clinical trials, the optimal time for delivery of bone marrow mononuclear cells (BMCs) after myocardial infarction is unclear. We compared the viability and effects of transplanted BMCs...
2.
Hung T, Suzuki Y, Urashima T, Caffarelli A, Hoyt G, Sheikh A, et al.
Circ Cardiovasc Imaging . 2009 Oct; 1(1):6-13. PMID: 19808509
Background: We tested the hypothesis that multimodality imaging of mouse embryonic stem cells (mESCs) provides accurate assessment of cellular location, viability, and restorative potential after transplantation into different zones of...
3.
Govaert J, Swijnenburg R, Schrepfer S, Xie X, Van der Bogt K, Hoyt G, et al.
J Heart Lung Transplant . 2009 Sep; 28(11):1158-1165.e1. PMID: 19782602
Background: Autologous bone marrow mononuclear cell (BMMC) therapy has shown promise for improving cardiac function after myocardial infarction. The efficiency of such therapy for diabetic patients remains unknown. Methods: BMMCs...
4.
Huang M, Chen Z, Hu S, Jia F, Li Z, Hoyt G, et al.
Circulation . 2009 Sep; 120(11 Suppl):S230-7. PMID: 19752373
Background: Conventional plasmids for gene therapy produce low-level and short-term gene expression. In this study, we develop a novel nonviral vector that robustly and persistently expresses the hypoxia-inducible factor-1 alpha...
5.
Li Z, Lee A, Huang M, Chun H, Chung J, Chu P, et al.
J Am Coll Cardiol . 2009 Apr; 53(14):1229-40. PMID: 19341866
Objectives: The goal of this study is to characterize resident cardiac stem cells (CSCs) and investigate their therapeutic efficacy in myocardial infarction by molecular imaging methods. Background: CSCs have been...
6.
Van der Bogt K, Schrepfer S, Yu J, Sheikh A, Hoyt G, Govaert J, et al.
Transplantation . 2009 Mar; 87(5):642-52. PMID: 19295307
Background: Mesenchymal stem cells hold promise for cardiovascular regenerative therapy. Derivation of these cells from the adipose tissue might be easier compared with bone marrow. However, the in vivo fate...
7.
Hendry 2nd S, Van der Bogt K, Sheikh A, Arai T, Dylla S, Drukker M, et al.
J Thorac Cardiovasc Surg . 2008 Oct; 136(4):1028-1037.e1. PMID: 18954646
Objective: Mouse embryonic stem cells have demonstrated potential to restore infarcted myocardium after acute myocardial infarction. Although the underlying mechanism remains controversial, magnetic resonance imaging has provided reliable in vivo...
8.
Huang M, Chan D, Jia F, Xie X, Li Z, Hoyt G, et al.
Circulation . 2008 Oct; 118(14 Suppl):S226-33. PMID: 18824759
Background: During hypoxia, upregulation of hypoxia inducible factor-1 alpha transcriptional factor can activate several downstream angiogenic genes. However, hypoxia inducible factor-1 alpha is naturally degraded by prolyl hydroxylase-2 (PHD2) protein....
9.
Van der Bogt K, Sheikh A, Schrepfer S, Hoyt G, Cao F, Ransohoff K, et al.
Circulation . 2008 Oct; 118(14 Suppl):S121-9. PMID: 18824743
Background: A comparative analysis of the efficacy of different cell candidates for the treatment of heart disease remains to be described. This study is designed to evaluate the therapeutic efficacy...
10.
Kutschka I, Sheikh A, Sista R, Hendry S, Chun H, Hoyt G, et al.
ILAR J . 2008 May; 49:E1-7. PMID: 18506056
Acquisition of echocardiographic data from rodents is subject to wide variability due to variations in technique. We hypothesize that a dedicated imaging platform can aid in standardization of technique and...