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Grant Backer

Explore the profile of Grant Backer including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 69
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Recent Articles
1.
Silverwood S, Backer G, Galloway A, Reid K, Jeter A, Harrison M
BMJ Oncol . 2025 Jan; 3(1):e000404. PMID: 39886168
Objective: Early detection of ovarian cancer can improve patient outcomes; however, screening tests can yield false-positive results, leading to unnecessary surgical interventions. This systematic review explores the prevalence of false-positive...
2.
Hull B, Miller K, Corban C, Backer G, Sheehan S, Korstanje R, et al.
Biomolecules . 2024 May; 14(5). PMID: 38786006
Age is the primary risk factor for neurodegenerative diseases such as Alzheimer's and Huntington's disease. Alzheimer's disease is the most common form of dementia and a leading cause of death...
3.
Dang H, Castro-Portuguez R, Espejo L, Backer G, Freitas S, Spence E, et al.
Nat Commun . 2023 Dec; 14(1):8338. PMID: 38097593
Tryptophan metabolism through the kynurenine pathway influences molecular processes critical to healthy aging including immune signaling, redox homeostasis, and energy production. Aberrant kynurenine metabolism occurs during normal aging and is...
4.
Yen R, Barr P, Cochran N, Aarts J, Legare F, Reed M, et al.
MDM Policy Pract . 2019 Nov; 4(2):2381468319885871. PMID: 31742232
We aimed to conduct a multinational cross-sectional online survey of medical students' attitudes toward, knowledge of, and experience with shared decision making (SDM). We conducted the survey from September 2016...
5.
Reilly C, Backer G, Basta D, Riblet N, Hofley P, Gallagher M
Allergy Asthma Proc . 2018 Nov; 39(6):420-429. PMID: 30401320
The majority of patients for elective surgery and with a history of penicillin allergy are placed on alternative prophylactic antibiotic therapies, which have been associated with the emergence of multidrug-resistant...
6.
Backer G, Eddy S, Sheehan S, Takemon Y, Reznichenko A, Savage H, et al.
Physiol Genomics . 2018 Apr; 50(8):543-552. PMID: 29652635
Mesangial matrix expansion is an important process in the initiation of chronic kidney disease, yet the genetic factors driving its development are unknown. Our previous studies have implicated Far2 as...
7.
Sutphin G, Backer G, Sheehan S, Bean S, Corban C, Liu T, et al.
Aging Cell . 2017 Apr; 16(4):672-682. PMID: 28401650
We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on orthology to human genes differentially expressed with age. We find substantial enrichment in genes for...
8.
Wang L, Liu R, Li D, Lin S, Fang X, Backer G, et al.
Am J Transl Res . 2012 Sep; 4(3):347-56. PMID: 22937211
A large number of risk alleles have been identified for multiple sclerosis (MS). However, how genetic variations may affect pathogenesis remains largely unknown for most risk alleles. Through direct sequencing...