Graham R Leggatt
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Explore the profile of Graham R Leggatt including associated specialties, affiliations and a list of published articles.
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60
Citations
975
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Recent Articles
1.
Dang T, Gillinder K, Nguyen Q, Mulay O, Vo T, Mehdi A, et al.
Clin Transl Immunology
. 2024 Dec;
13(12):e70018.
PMID: 39619016
Objectives: Langerhans cells (LCs) are epithelial antigen-presenting cells (APC) contributing to immune surveillance. LCs depend on interleukin 34 (IL34) production by epithelial cells. This study aimed to uncover mechanisms of...
2.
Berrell N, Sadeghirad H, Blick T, Bidgood C, Leggatt G, OByrne K, et al.
Med Res Rev
. 2023 Dec;
44(3):1121-1146.
PMID: 38146814
Cancer heterogeneity remains a significant challenge for effective cancer treatments. Altered energetics is one of the hallmarks of cancer and influences tumor growth and drug resistance. Studies have shown that...
3.
Wright Q, Gonzalez Cruz J, Wells J, Leggatt G
Cancers (Basel)
. 2021 Jul;
13(13).
PMID: 34282763
Non-melanoma skin cancers (NMSC) have a higher incidence than all other cancers combined with cutaneous squamous cell carcinoma (cSCC), capable of metastasis, representing approximately 20% of NMSCs. Given the accessibility...
4.
Zeng Z, Chew H, Cruz J, Leggatt G, Wells J
Int J Mol Sci
. 2021 Apr;
22(6).
PMID: 33809369
T cells play a key role in tumour surveillance, both identifying and eliminating transformed cells. However, as tumours become established they form their own suppressive microenvironments capable of shutting down...
5.
Bashaw A, Zhou C, Yu M, Tolley L, Leggatt G, Frazer I, et al.
J Invest Dermatol
. 2020 Nov;
141(5):1264-1273.e3.
PMID: 33129828
High-risk human papillomavirus infection can induce cervical and other intraepithelial neoplasia and invasive cancers. A transgenic mouse expressing keratin 14 promotor-driven HPV16 E7 oncoprotein exhibits epithelial hyperplasia and mimics many...
6.
Kobayashi T, Lam P, Jiang H, Bednarska K, Gloury R, Murigneux V, et al.
Blood
. 2020 Aug;
136(26):3004-3017.
PMID: 32818230
Natural killer (NK) cells play critical roles in protection against hematological malignancies but can acquire a dysfunctional state, which limits antitumor immunity. However, the underlying reasons for this impaired NK...
7.
Tuong Z, Lewandowski A, Bridge J, Cruz J, Yamada M, Lambie D, et al.
Sci Rep
. 2019 Nov;
9(1):17754.
PMID: 31780824
Actinic Keratosis (AK), Intraepidermal Carcinoma (IEC), and Squamous Cell Carcinoma (SCC) are generally considered to be advancing stages of the same disease spectrum. However, while AK often regress spontaneously, and...
8.
Bashaw A, Teoh S, Tuong Z, Leggatt G, Frazer I, Chandra J
J Invest Dermatol
. 2019 Jun;
139(12):2467-2476.e3.
PMID: 31207230
Human papillomaviruses infect keratinocytes and can lead to hyperproliferative dysplasia and malignant transformation if not cleared by the immune system. Human papillomavirus has evolved an array of mechanisms to evade...
9.
Kuo P, Teoh S, Tuong Z, Leggatt G, Mattarollo S, Frazer I
Front Immunol
. 2019 Jan;
9:2896.
PMID: 30619266
"High-risk" human papillomaviruses (HPV) infect keratinocytes of squamous epithelia. The HPV16E7 protein induces epithelial hyperplasia by binding Rb family proteins and disrupting cell cycle termination. Murine skin expressing HPV16E7 as...
10.
Kuo P, Zeng Z, Salim N, Mattarollo S, Wells J, Leggatt G
Front Med (Lausanne)
. 2018 Oct;
5:271.
PMID: 30320116
Chemokines and their receptors play an important role in the recruitment, activation and differentiation of immune cells. The chemokine receptor, CXCR3, and its ligands, CXCL9, CXCL10, and CXCL11 are key...