Graham Molineux
Overview
Explore the profile of Graham Molineux including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
467
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Recent Articles
1.
McElroy P, Wei P, Buck K, Sinclair A, Eschenberg M, Sasu B, et al.
Exp Hematol
. 2015 Mar;
43(6):479-87.
PMID: 25754671
Chemotherapy-induced thrombocytopenia can lead to chemotherapy treatment delays or dose reductions. The ability of romiplostim, a thrombopoietin (TPO) mimetic, to promote platelet recovery in a mouse model of multicycle chemotherapy/radiation...
2.
Cooke K, Hinkle B, Salimi-Moosavi H, Foltz I, King C, Rathanaswami P, et al.
Blood
. 2013 Aug;
122(17):3054-61.
PMID: 23945155
Iron maldistribution has been implicated in the etiology of many diseases including the anemia of inflammation (AI), atherosclerosis, diabetes, and neurodegenerative disorders. Iron metabolism is controlled by hepcidin, a 25-amino-acid...
3.
Ross S, Tran L, Winters A, Lee K, Plewa C, Foltz I, et al.
Cell Metab
. 2012 Jun;
15(6):905-17.
PMID: 22682226
Ferroportin is the primary means of cellular iron efflux and a key component of iron metabolism. Hepcidin regulates Fpn activity by inducing its internalization and degradation. The mechanism of internalization...
4.
Molineux G
Ann N Y Acad Sci
. 2011 Mar;
1222:55-63.
PMID: 21434943
Comprised of peptide and carrier components in an overall structure superficially resembling an antibody, romiplostim is the prototype of a new class of protein therapeutics called peptibodies. Romiplostim (AMG 531,...
5.
6.
Sasu B, Li H, Rose M, Arvedson T, Doellgast G, Molineux G
Blood Cells Mol Dis
. 2010 Aug;
45(3):238-45.
PMID: 20800515
Anemia in cancer patients can result from a complex interaction of numerous factors including iron deficiency, inflammation, toxicity related to therapy and effect of cancer on the marrow. Determining effective...
7.
Molineux G, Newland A
Br J Haematol
. 2010 Mar;
150(1):9-20.
PMID: 20298251
Immune thrombocytopenia (ITP) is an autoimmune disorder characterised by abnormally low platelet counts (<100 x 10(9)/l), purpura, and bleeding episodes, and can be categorised in three phases: newly-diagnosed, persistent, and...
8.
Sasu B, Cooke K, Arvedson T, Plewa C, Ellison A, Sheng J, et al.
Blood
. 2010 Jan;
115(17):3616-24.
PMID: 20053755
Iron maldistribution has been implicated in multiple diseases, including the anemia of inflammation (AI), atherosclerosis, diabetes, and neurodegenerative disorders. Iron metabolism is controlled by hepcidin, a 25-amino acid peptide. Hepcidin...
9.
Agoram B, Aoki K, Doshi S, Gegg C, Jang G, Molineux G, et al.
J Pharm Sci
. 2008 Oct;
98(6):2198-211.
PMID: 18837016
Erythropoietin (EPO) receptor-mediated endocytosis and degradation in the bone marrow has been hypothesized to be the major clearance pathway of erythropoiesis-stimulating agents (ESA). We investigated the role of this pathway...
10.
de Kruijf E, van Pel M, Hagoort H, Kruysdijk D, Molineux G, Willemze R, et al.
Hum Immunol
. 2007 Apr;
68(5):368-74.
PMID: 17462504
Administration of recombinant-human G-CSF (rhG-CSF) is highly efficient in mobilizing hematopoietic stem and progenitor cells (HSC/HPC) from the bone marrow (BM) toward the peripheral blood. This study was designed to...