Graham L Radford-Smith
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Explore the profile of Graham L Radford-Smith including associated specialties, affiliations and a list of published articles.
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39
Citations
2356
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Recent Articles
1.
Kumar R, Brown A, Okano S, Simms L, Lord A, OSullivan T, et al.
Sci Rep
. 2024 Oct;
14(1):23501.
PMID: 39379529
Colorectal cancer is a major cause of cancer-related deaths within the Australian population. Colonoscopy and polypectomy represent effective forms of prevention. Factors such as diabetes, hypertension and dyslipidaemia have been...
2.
Radford-Smith G, Afrin S
Intern Med J
. 2022 Nov;
52(11):2018.
PMID: 36404112
No abstract available.
3.
Mortlock S, Lord A, Montgomery G, Zakrzewski M, Simms L, Krishnaprasad K, et al.
J Crohns Colitis
. 2022 Sep;
17(2):277-288.
PMID: 36111848
Background And Aims: Ulcerative colitis [UC] is a major form of inflammatory bowel disease globally. Phenotypic heterogeneity is defined by several variables including age of onset and disease extent. The...
4.
Afrin S, Simms L, Lord A, Radford-Smith G
Intern Med J
. 2022 Mar;
52(11):1971-1977.
PMID: 35289057
Background: Thiopurine-related adverse events such as leukopenia, liver dysfunction and pancreatitis are associated with variants in the NUDT15 gene. Loss-of-function (low or no enzyme activity) alleles are more common in...
5.
Lim M, Lord A, Simms L, Hanigan K, Edmundson A, Rickard M, et al.
Ann Coloproctol
. 2020 Sep;
37(5):318-325.
PMID: 32972106
Purpose: We report outcomes and evaluate patient factors and the impact of surgical evolution on outcomes in consecutive ulcerative colitis patients who had restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA)...
6.
Landi M, Bishop D, Macgregor S, Machiela M, Stratigos A, Ghiorzo P, et al.
Nat Genet
. 2020 Apr;
52(5):494-504.
PMID: 32341527
Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly genotyped) and 375,188 controls identified 54 significant (P ...
7.
Patrick D, Doecke J, Irwin J, Hanigan K, Simms L, Howlett M, et al.
Intern Med J
. 2019 Oct;
50(7):823-829.
PMID: 31589361
Background And Aims: Many patients presenting with an acute severe ulcerative colitis to a regional hospital are transferred to a metropolitan hospital for specialised care. This study aimed to evaluate...
8.
Wu Y, Ghaly S, Kerr S, Jackson B, Hanigan K, Martins D, et al.
Dig Dis Sci
. 2019 Sep;
65(4):1172-1179.
PMID: 31493039
Background: Retrospective studies observe an increased risk of keratinocyte carcinomas (KCs) in patients with inflammatory bowel disease (IBD) on thiopurine (TP) medication. The role of traditional risk factors such as...
9.
Zakrzewski M, Simms L, Brown A, Appleyard M, Irwin J, Waddell N, et al.
J Crohns Colitis
. 2018 Nov;
13(4):451-461.
PMID: 30445599
Background And Aims: This study aimed to characterize the mucosa-associated microbiota in ileal Crohn's disease [CD] patients and in healthy controls in terms of host genotype and inflammation status. Methods:...
10.
Tye H, Yu C, Simms L, de Zoete M, Kim M, Zakrzewski M, et al.
Nat Commun
. 2018 Sep;
9(1):3728.
PMID: 30214011
Anti-microbial signaling pathways are normally triggered by innate immune receptors when detecting pathogenic microbes to provide protective immunity. Here we show that the inflammasome sensor Nlrp1 aggravates DSS-induced experimental mouse...