Graeme A Deuchar
Overview
Explore the profile of Graeme A Deuchar including associated specialties, affiliations and a list of published articles.
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15
Citations
323
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0
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Recent Articles
1.
Darcot E, Colotti R, Brennan D, Deuchar G, Santosh C, van Heeswijk R
NMR Biomed
. 2019 Nov;
33(1):e4212.
PMID: 31724252
The two main challenges that prevent the translation of fluorine-19 ( F) MRI for inflammation monitoring or cell tracking into clinical practice are (i) the relatively low signal-to-noise ratio generated...
2.
Deuchar G, van Kralingen J, Work L, Santosh C, Muir K, McCabe C, et al.
Transl Stroke Res
. 2018 Dec;
10(5):583-595.
PMID: 30506268
In acute stroke patients, penumbral tissue is non-functioning but potentially salvageable within a time window of variable duration and represents target tissue for rescue. Reperfusion by thrombolysis and/or thrombectomy can...
3.
Deuchar G, Brennan D, Holmes W, Shaw M, Macrae I, Santosh C
Theranostics
. 2018 Mar;
8(6):1706-1722.
PMID: 29556351
The ability to identify metabolically active and potentially salvageable ischaemic penumbra is crucial for improving treatment decisions in acute stroke patients. Our solution involves two complementary novel MRI techniques (Glasgow...
4.
Percie du Sert N, Alfieri A, Allan S, Carswell H, Deuchar G, Farr T, et al.
J Cereb Blood Flow Metab
. 2017 Aug;
37(11):3488-3517.
PMID: 28797196
Most in vivo models of ischaemic stroke target the middle cerebral artery and a spectrum of stroke severities, from mild to substantial, can be achieved. This review describes opportunities to...
5.
Robertson C, McCabe C, Lopez-Gonzalez M, Deuchar G, Dani K, Holmes W, et al.
Int J Stroke
. 2014 Jul;
10(1):42-50.
PMID: 25042078
Background: Acute ischemic stroke is common and disabling, but there remains a paucity of acute treatment options and available treatment (thrombolysis) is underutilized. Advanced brain imaging, designed to identify viable...
6.
Deuchar G, Brennan D, Griffiths H, Macrae I, Santosh C
J Cereb Blood Flow Metab
. 2013 Jun;
33(9):1422-8.
PMID: 23801243
Accurate imaging of ischemic penumbra is crucial for improving the management of acute stroke patients. T2* magnetic resonance imaging (MRI) combined with a T2*oxygen challenge (T2*OC) is being developed to...
7.
Holmes W, Lopez-Gonzalez M, Gallagher L, Deuchar G, Macrae I, Santosh C
NMR Biomed
. 2011 Jul;
25(2):295-304.
PMID: 21751274
We describe a novel magnetic resonance imaging technique to directly assess the metabolic integrity of penumbral tissue following stroke. For ischemically stressed tissue to be salvageable, it has to be...
8.
Baskerville T, Deuchar G, McCabe C, Robertson C, Holmes W, Santosh C, et al.
J Cereb Blood Flow Metab
. 2011 May;
31(8):1799-806.
PMID: 21559031
Accurate imaging of the ischemic penumbra is a prerequisite for acute clinical stroke research. T(2)(*) magnetic resonance imaging (MRI) combined with an oxygen challenge (OC) is being developed to detect...
9.
Deuchar G, McLean D, Hadoke P, Brownstein D, Webb D, Mullins J, et al.
Endocrinology
. 2010 Nov;
152(1):236-246.
PMID: 21106873
Mineralocorticoid receptor (MR) activation is proinflammatory and proatherogenic. Antagonism of MR improves survival in humans with congestive heart failure caused by atherosclerotic disease. In animal models, activation of MR exacerbates...
10.
TNFalpha is required to confer protection in an in vivo model of classical ischaemic preconditioning
Deuchar G, Opie L, Lecour S
Life Sci
. 2007 Feb;
80(18):1686-91.
PMID: 17316703
Although Tumor Necrosis Factor alpha (TNFalpha) is used as a preconditioning mimetic in vitro, its role in ischaemic preconditioning (IPC) has not been clearly defined. Here, we propose to use...