Grace S Shieh
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Explore the profile of Grace S Shieh including associated specialties, affiliations and a list of published articles.
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19
Citations
159
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Recent Articles
1.
Tseng Y, Chang Y, Mekala V, Liu T, Chang J, Shieh G
Front Genet
. 2024 Oct;
15:1423714.
PMID: 39385933
To identify rare variants (RVs) of gout, we sequenced the whole genomes of 321 male gout patients and combined these with those of 64 male gout patients and 682 normal...
2.
Yuan S, Chen Y, Tsai C, Chen H, Shieh G
Front Genet
. 2023 Jul;
14:1217414.
PMID: 37519889
Targeted therapies and chemotherapies are prevalent in cancer treatment. Identification of predictive markers to stratify cancer patients who will respond to these therapies remains challenging because patient drug response data...
3.
Tripathi Y, Chatla S, Chang Y, Huang L, Shieh G
PLoS One
. 2022 Jun;
17(6):e0270270.
PMID: 35727808
Nonlinear correlation exists in many types of biomedical data. Several types of pairwise gene expression in humans and other organisms show nonlinear correlation across time, e.g., genes involved in human...
4.
Shieh G
J Pers Med
. 2022 Jan;
12(1).
PMID: 35055413
Two genes are said to have synthetic lethal (SL) interactions if the simultaneous mutations in a cell lead to lethality, but each individual mutation does not. Targeting SL partners of...
5.
Wang H, Chiang C, Liu T, Wu C, Chen Y, Chang J, et al.
Front Genet
. 2021 May;
12:643461.
PMID: 33936170
Oral squamous cell carcinoma (OSCC) has a high mortality rate (∼50%), and the 5-year overall survival rate is not optimal. Cyto- and histopathological examination of cancer tissues is the main...
6.
Hsu Y, Hsiao Y, Kao T, Chang J, Shieh G
Sci Rep
. 2017 Nov;
7(1):15959.
PMID: 29162841
Due to lack of normal samples in clinical diagnosis and to reduce costs, detection of small-scale mutations from tumor-only samples is required but remains relatively unexplored. We developed an algorithm...
7.
Chang J, Chen C, Wu Y, Che T, Huang Y, Yeh K, et al.
Oncotarget
. 2016 Sep;
7(45):73664-73680.
PMID: 27655641
Two genes are called synthetic lethal (SL) if their simultaneous mutation leads to cell death, but mutation of either individual does not. Targeting SL partners of mutated cancer genes can...
8.
Hwang J, Sung W, Tu H, Hsieh K, Yeh C, Chen C, et al.
PLoS One
. 2015 Oct;
10(10):e0139435.
PMID: 26431531
Synthetic lethality arises when a combination of mutations in two or more genes leads to cell death. However, the prognostic role of concordant overexpression of synthetic lethality genes in protein...
9.
Tiong K, Chang K, Yeh K, Liu T, Wu J, Hsieh P, et al.
Neoplasia
. 2014 Jun;
16(5):441-50.
PMID: 24947187
Two genes are called synthetic lethal (SL) if their simultaneous mutations lead to cell death, but each individual mutation does not. Targeting SL partners of mutated cancer genes can kill...
10.
Wu J, Sun Y, Hsieh P, Shieh G
Gene
. 2012 Dec;
518(1):139-44.
PMID: 23246694
Both transcription factors (TFs) and microRNAs (miRNAs) regulate gene expression. TFs activate or suppress the initiation of the transcription process and miRNAs regulate mRNAs post-transcriptionally, thus forming a temporally ordered...